Results 141 to 150 of about 24,059,316 (329)

Artificial intelligence (AI)‐driven strategic business model innovations in small‐ and medium‐sized enterprises. Insights on technological and strategic enablers for carbon neutral businesses [PDF]

, 2023
Aqueeb Sohail Shaik, Safiya Mukhtar Alshibani, Girish Jain, Bhumika Gupta, Ankit Mehrotra   +4 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment

Frontiers in Pharmacology
BackgroundFerroptosis is an intracellular iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Increasing evidence indicated that ferroptosis plays a crucial role in suppressing tumors, thus providing new opportunities for ...
Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao Wang, Yao Wang   +9 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Fisetin reverses the negative effect of Lambda-Cyhalothrin on the maturation process of porcine oocytes in vitro by downregulating GRP78 levels

Ecotoxicology and Environmental Safety
Lambda-Cyhalothrin (LCT), a potent insecticide, is renowned for its efficacy, rapid onset, and broad-spectrum insecticidal activity. With rising annual demand for LCT, environmental concerns have similarly intensified.
Xiu-wen Yuan, Jia-jun Ren, Neng-hao Cao, Xue-rui Yao, Xing-wei Liang, Nam-hyung Kim, Yong-nan Xu, Ying-hua Li   +7 more
doaj   +1 more source

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

, 1992
Gregory Young, Joel Keizer
openalex   +2 more sources

Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model [PDF]

, 2018
Yanlin Wang-Fischer, Tina Garyantes
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Bayesian modelling of inseparable space‐time variation in disease risk

, 2000
Leonhard Knorr‐Held
openalex   +1 more source

Modeling Language Variation and Universals: A Survey on Typological Linguistics for Natural Language Processing [PDF]

, 2019
Edoardo Maria Ponti, Helen O’Horan, Yevgeni Berzak, Ivan Vulić, Roi Reichart, Thierry Poibeau, Ekaterina Shutova, Anna Korhonen   +7 more
openalex   +1 more source