Results 231 to 240 of about 22,680,672 (365)

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Pediatric genetic counselor use and perception of various clinic models. [PDF]

J Genet Couns
Franciskato E, Brokamp E, Jasper E, Munroe C, Britton J, Duncan L.   +5 more
europepmc   +1 more source

Description of a Machine for Shaping the Models Used in Experiments on Forms of Ships [PDF]

, 1873
William Froude
openalex   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Enhanced Series and Atomic Models [PDF]

, 1914
Arthur William Conway
openalex   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Fisetin reverses the negative effect of Lambda-Cyhalothrin on the maturation process of porcine oocytes in vitro by downregulating GRP78 levels

Ecotoxicology and Environmental Safety
Lambda-Cyhalothrin (LCT), a potent insecticide, is renowned for its efficacy, rapid onset, and broad-spectrum insecticidal activity. With rising annual demand for LCT, environmental concerns have similarly intensified.
Xiu-wen Yuan, Jia-jun Ren, Neng-hao Cao, Xue-rui Yao, Xing-wei Liang, Nam-hyung Kim, Yong-nan Xu, Ying-hua Li   +7 more
doaj  

Retraining and evaluation of machine learning and deep learning models for seizure classification from EEG data. [PDF]

Sci Rep
Carvajal-Dossman JP, Guio L, García-Orjuela D, Guzmán-Porras JJ, Garces K, Naranjo A, Maradei-Anaya SJ, Duitama J.   +7 more
europepmc   +1 more source

Description of the Experimental Apparatus and Shaping Machine for Ship Models at the Admiralty Experiment Works, Haslar [PDF]

, 1893
R. Edmund Frodue
openalex   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source