Results 131 to 140 of about 1,986,272 (219)

New models for human disease from the International Mouse Phenotyping Consortium. [PDF]

Mamm Genome, 2019
Cacheiro P, Haendel MA, Smedley D, International Mouse Phenotyping Consortium and the Monarch Initiative.   +3 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease. [PDF]

Int J Mol Sci
White AG, Elias E, Orozco A, Robinson SA, Manners MT.   +4 more
europepmc   +1 more source

Genetically engineered pigs as models for human disease. [PDF]

Dis Model Mech, 2018
Perleberg C, Kind A, Schnieke A.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Gemin6 promotes c‐Myc stabilisation and non‐small cell lung cancer progression via accelerating AURKB mRNA maturation

Clinical and Translational Medicine, 2022
Jie Lin, Baiyang Liu, Yong Zhang, Li Lv, Dating Cheng, Wenhui Zhang, Yulin Shi, Xiulin Jiang, Lin Tang, Yixiao Yuan, Haoqing Zhai, Qiushuo Shen, Qiuxia Xiong, Zhixian Jin, Yongbin Chen, Cuiping Yang   +15 more
doaj   +1 more source

Brainstem Gliomas: New Models Recapitulate Human Disease and Deepen Our Understanding. [PDF]

Neurosurgery, 2019
Wedemeyer MA, Attenello FJ.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Living inside the box: environmental effects on mouse models of human disease. [PDF]

Dis Model Mech, 2018
Sundberg JP, Schofield PN.
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source