Results 121 to 130 of about 1,443,825 (234)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Effect of Implant Angulation on Digital Impression Accuracy of Three-Unit Implant-Supported Restorations

International Dental Journal
Introduction and Aims: This study evaluated the effect of implant angulation on the accuracy of digital impressions for 3-unit implant-supported fixed partial dentures obtained with 2 intraoral scanners.
Narges Ameri, Mahnaz Arshad, Melika Ghaffari, Sareh Habibzadeh, Seyed Ali Mosaddad   +4 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Influence of scan body geometry on the trueness of intraoral scanning

BDJ Open
Purpose This study aimed to evaluate the influence of scan body geometry on the trueness of intraoral scanner (IOS) acquisitions. Methods An in vitro study was conducted using three groups of scan bodies with varying designs.
Eduardo Anitua, Asier Lazcano, Beatriz Anitua, Asier Eguia, Mohammad Hamdan Alkhraisat   +4 more
doaj   +1 more source

Enhancing Safety in Automatic Electric Vehicle Charging: A Novel Collision Classification Approach

Applied Sciences
With the rise of electric vehicles, autonomous driving, and valet parking technologies, considerable research has been dedicated to automatic charging solutions. While the current focus lies on charging robot design and the visual positioning of charging
Haoyu Lin, Pengkun Quan, Zhuo Liang, Dongbo Wei, Shichun Di   +4 more
doaj   +1 more source

Some Results on Probabilities of Moderate Deviations

Acta Mathematica Sinica, English Series
Let $\{X, X_{n}; n \geq 1\}$ be a sequence of i.i.d. non-degenerate real-valued random variables with $\mathbb{E}X^{2} < \infty$. Let $S_{n} = \sum_{i=1}^{n} X_{i}$, $n \geq 1$. Let $g(\cdot): ~[0, \infty) \rightarrow [0, \infty)$ be a nondecreasing regularly varying function with index $ρ\geq 0$ and $\lim_{t \rightarrow \infty} g(t) = \infty$. Let $
Li, Deli, Miao, Yu, Qi, Yongcheng
openaire   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Hidden impacts of ocean warming and acidification on biological responses of marine animals revealed through meta-analysis

Nature Communications
Conflicting results remain on the impacts of climate change on marine organisms, hindering our capacity to predict the future state of marine ecosystems. To account for species-specific responses and for the ambiguous relation of most metrics to fitness,
Katharina Alter, Juliette Jacquemont, Joachim Claudet, María E. Lattuca, María E. Barrantes, Stefano Marras, Patricio H. Manríquez, Claudio P. González, Daniel A. Fernández, Myron A. Peck, Carlo Cattano, Marco Milazzo, Felix C. Mark, Paolo Domenici   +13 more
doaj   +1 more source