Results 151 to 160 of about 15,435,973 (360)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Short-Term Effect of Store-Level Promotions on Store Choice and the Moderating Role of Individual Variables. [PDF]

The short-term effect of store-level promotions (weekly flyers, radio and outdoor advertising) on grocery store choice is investigated. We estimate household-level multinomial logit (MNL) models of store choice on panel data, using promotional variables,
Volle, Pierre
core   +3 more sources

Effect of Blue Finance and Marine Environmental Quality on the Marine Fishery Economy

Fishes
This study investigates the effects of blue finance and marine environmental quality of the marine fishery economy using panel data for marine fisheries in China’s coastal provinces spanning 2011–2023.
Yiying Jiang, Lei Huang, Xiya Zhu, Weirong Song, Yang Liu   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The moderating effect of working years on nurses’ medical narrative ability and empathy ability: a cross-sectional survey study

BMC Nursing
Objective To explore the moderating effect of working years on nurses’ medical narrative ability and empathy ability. Methods A multi-center cross-sectional survey was conducted among 1920 clinical nurses from 12 general hospitals of different levels in ...
Hailing Qiu, Jie Huang, Tingzhi Li, Chao Yang, Yingyan Pan, Wanying Su, Qiong Qi, Fanling Li, Jing Yang, Yajuan Wu, Siqi Zhang, Jie Wen   +11 more
doaj   +1 more source

PENGARUH VARIABEL-VARIABEL MONETER TERHADAP KINERJA PERBANKAN ISLAM : UKURAN PERUSAHAAN SEBAGAI VARIABEL MODERAT [PDF]

, 2017
The growth and competition of Islamic banking in Indonesia is faster and tight, because of that the Islamic banks need to improve its performance in order to attract investors and clients, meanwhile monetary variables influencing on performance of ...
Martokromo, Sriyono Djemain
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Moderating Factors of Immediate, Dynamic, and Long-run Cross-Price Effects [PDF]

In this article the authors describe their comprehensive analysis of moderating factors of cross-brand effects of price changes and contribute to the literature in five major ways.
Fok, D., Horváth, C.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The effect of shipping efficiency on marine petroleum pollution: an empirical analysis of China’s 11 coastal regions

Frontiers in Marine Science
IntroductionMarine petroleum pollution has adversely affected marine ecosystems and human living environments, while improvements in shipping efficiency offer a new avenue for mitigating such pollution.MethodsBased on panel data from 11 coastal regions ...
Xina Ji, Xingong Ding, Xingong Ding, Wanli Hu, Yuxi Qiu   +4 more
doaj   +1 more source