Results 91 to 100 of about 143,475 (289)

Navigating the Challenges of Technological Advancement: Iqbal’s Philosophical Insights on Moderation and Humanity in the Digital Age

Al ' Adalah
This study delves into the philosophical insights of Muhammad Iqbal regarding the interaction between humanity, moderation, and technology in the digital age.
Hero Gefthi Firnando
doaj   +1 more source

Assessment of group work in initial teacher education and training

South African Journal of Education, 2018
This study records findings of a study carried out in a group of 100 students at a South African university. This study examines the group’s assignments as a way of gathering evidence about pre-service teachers’ achievements in the process of education ...
Mamsi Ethel Khuzwayo
doaj   +1 more source

Practices of Islamic education teachers in promoting moderation (wasatiyyah) values among high school students in Kuwait: challenges and obstacles

Cogent Education
Moderation in Islam means the middle position between two opposite, exaggerated views, with neither view dominating the other. The study questions are: What are the practices of Islamic education teachers in promoting moderation values through their own ...
M. Alabdulhadi, Kalthoum Alkandari
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Islamic Understanding in the Digital Age among University Student Associations

Millati: Journal of Islamic Studies and Humanities
The development of technology in the 4.0 era changes the order of human thought and performance to be faster, more efficient, and more effective in different sectors of life, one of which is in finding information.
Muhammad Khalilullah, Rian Vebrianto, Mahyudin Syukri , Iqbal Miftakhul Mujtahid, Dilva Hardila   +4 more
doaj   +1 more source

Moderating Effects of Cortisol on Neural-Cognitive Association in Cognitively Normal Elderly Subjects

Frontiers in Aging Neuroscience, 2017
Cortisol homeostasis is important for healthy brain and cognitive aging. The aim of the current study is to investigate the role of serum cortisol levels in the relationship between regional brain volumes and cognitive processing speed in a group of ...
Way K. W. Lau, Way K. W. Lau, Mei Kei Leung, Mei Kei Leung, Andrew C. K. Law, Andrew C. K. Law, Tatia M. C. Lee, Tatia M. C. Lee, Tatia M. C. Lee, Tatia M. C. Lee   +9 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source