Results 91 to 100 of about 241,852 (360)

Noisy Information, Interest Rate Shocks and the Great Moderation [PDF]

open access: yes
In this paper we quantitatively evaluate the hypothesis that the Great Moderation is partly the result of a less activist monetary policy. We simulate a New Keynesian model where the central bank can only observe a noisy estimate of the output gap and ...
Johann Scharler, Eric Mayer
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Is the Great Moderation over? an empirical analysis [PDF]

open access: yes
The economy of the United States was markedly less volatile in the past two to three decades than in prior periods. The nation enjoyed long economic expansions in each of the last three decades, interrupted by recessions in 1990-91 and 2001 that were ...
Todd E. Clark
core  

Privacy-preserving Moderation of Illegal Online Content [PDF]

open access: yes
This CETaS Research Report examines promising content moderation solutions that can help social media platforms and end-to-end encrypted (E2EE) services fulfil their new legal duties to remove illegal online content under the UK Online Safety Act (OSA)
Latham, Annabel   +5 more
core   +1 more source

Practices of Islamic education teachers in promoting moderation (wasatiyyah) values among high school students in Kuwait: challenges and obstacles

open access: yesCogent Education
Moderation in Islam means the middle position between two opposite, exaggerated views, with neither view dominating the other. The study questions are: What are the practices of Islamic education teachers in promoting moderation values through their own ...
M. Alabdulhadi, Kalthoum Alkandari
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

What's so Great about the Great Moderation? A Multi-Country Investigation of Time-Varying Volatilities of Output Growth and Inflation [PDF]

open access: yes
Changes in volatility of output growth and inflation are examined for eight countries with at least 140 years of uninterrupted data. Time-varying parameter vector autoregressions are used to estimate standard deviations of each variable.
Victor J. Valcarcel, John W. Keating
core  

The impact of coping and resilience on anxiety among older Australians

open access: yesAustralian Journal of Psychology, 2017
Objective: This study aims to explore the relationships between various coping types, resilience, and anxiety among older Australians. Particular attention is paid to whether resilience moderates coping's effect on anxiety.
Wendy Wen Li, Daniel J. Miller
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

VAR analysis and the Great Moderation [PDF]

open access: yes
Most analyses of the U.S. Great Moderation have been based on structural VAR methods, and have consistently pointed towards good luck as the main explanation for the greater macroeconomic stability of recent years.
Benati, Luca, Surico, Paolo
core  

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