Results 71 to 80 of about 5,460,179 (306)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

What's so Great about the Great Moderation? A Multi-Country Investigation of Time-Varying Volatilities of Output Growth and Inflation [PDF]

Changes in volatility of output growth and inflation are examined for eight countries with at least 140 years of uninterrupted data. Time-varying parameter vector autoregressions are used to estimate standard deviations of each variable.
Victor J. Valcarcel, John W. Keating
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Evaluating the Normative Boundaries of Religious Moderation in Tafsir Moderasi Beragama through Muhammad Shahrur's Theory of Limits

QiST
Purpose - Despite increasing scholarly attention to religious moderation in Muslim-majority societies, there remains a lack of studies that systematically evaluate the normative boundaries of state-produced Qur'anic exegesis through an internally ...
Ahmad Mohammad Tidjani, Ahmad Mahfud, Zulfatul Wasilah, Aufal Muhammad Safii   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Towards Navigating Ethical Challenges in AI-Driven Healthcare Ad Moderation

Computers
The growing use of AI-driven content moderation on social media platforms has intensified ethical concerns, particularly in the context of healthcare advertising and misinformation.
Abraham Abby Sen, Jeen Mariam Joy, Murray E. Jennex   +2 more
doaj   +1 more source

Forecast Errors Before and After the Great Moderation [PDF]

This paper investigates the change in private-sector and Federal Reserve forecasts before and after the Great Moderation. We view the Great Moderation as a natural experiment.
Julie K. Smith, Edward N. Gamber, Matthew Weiss   +2 more
core  

Examining the tension between academic standards and inclusion for disabled students: the impact on marking of individual academics’ frameworks for assessment [PDF]

, 2010
This article draws on developing theory regarding assessment and marking to explore the impact of staff values regarding widening participation on grading decisions.
Bloxham, Susan, Ashworth, Mary, Pearce, Leonie   +2 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

From violence to voting : toward an Islamist theory of moderation.

, 2011
Moderation theory posits that inclusion in the political process will lead extremist parties to abandon violence and play by the rules of the political game.
Wheatley, Stephanie Renee, 1982-
core   +2 more sources