Results 71 to 80 of about 5,647,360 (304)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

What's so Great about the Great Moderation? A Multi-Country Investigation of Time-Varying Volatilities of Output Growth and Inflation [PDF]

open access: yes
Changes in volatility of output growth and inflation are examined for eight countries with at least 140 years of uninterrupted data. Time-varying parameter vector autoregressions are used to estimate standard deviations of each variable.
Victor J. Valcarcel, John W. Keating
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Forecast Errors Before and After the Great Moderation [PDF]

open access: yes
This paper investigates the change in private-sector and Federal Reserve forecasts before and after the Great Moderation. We view the Great Moderation as a natural experiment.
Julie K. Smith   +2 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Towards Navigating Ethical Challenges in AI-Driven Healthcare Ad Moderation

open access: yesComputers
The growing use of AI-driven content moderation on social media platforms has intensified ethical concerns, particularly in the context of healthcare advertising and misinformation.
Abraham Abby Sen   +2 more
doaj   +1 more source

VAR analysis and the Great Moderation [PDF]

open access: yes
Most analyses of the U.S. Great Moderation have been based on structural VAR methods, and have consistently pointed towards good luck as the main explanation for the greater macroeconomic stability of recent years.
Benati, Luca, Surico, Paolo
core  

Philosophical Root of Moderation Discourse in Iran’s Eleventh Presidential Election

open access: yes, 2018
Moderation was a triumphant discourse of Iran's eleventh presidential election. It’s a new attitude in the political realm and most of the movements relate themselves to it and each one interprete their actions according to moderation.
Ali Alihosseini   +2 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Evaluating the Normative Boundaries of Religious Moderation in Tafsir Moderasi Beragama through Muhammad Shahrur's Theory of Limits

open access: yesQiST
Purpose - Despite increasing scholarly attention to religious moderation in Muslim-majority societies, there remains a lack of studies that systematically evaluate the normative boundaries of state-produced Qur'anic exegesis through an internally ...
Ahmad Mohammad Tidjani   +3 more
doaj   +1 more source

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