Results 61 to 70 of about 5,647,360 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

PESAN MODERASI BERAGAMA FACEBOOK KH. AFIFUDDIN MUHAJIR DALAM MENGELOLA KERAGAMAN AGAMA PERSPEKTIF KEBEBASAN BERAGAMA DAN USHUL FIQH

Lisan Al-Hal: Jurnal Pengembangan Pemikiran dan Kebudayaan
This study examines the messages of religious moderation delivered by one of the scholars popular among millennials, KH. Afifuddin Muhajir, through his personal Facebook account.
Nahe'i Nahe'i, Moh Soleh Shofier
doaj   +1 more source

Procedural Information and Behavioral Control: Longitudinal Analysis of the Intention-Behavior Gap in the Context of Recycling

Recycling, 2018
The theory of planned behavior states that individuals act on their intentions, especially when they have behavioral control. The current study examines how seeking recycling-related procedural information—i.e., information about how and where to recycle—
Sonny Rosenthal
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Noisy Information, Interest Rate Shocks and the Great Moderation [PDF]

In this paper we quantitatively evaluate the hypothesis that the Great Moderation is partly the result of a less activist monetary policy. We simulate a New Keynesian model where the central bank can only observe a noisy estimate of the output gap and ...
Johann Scharler, Eric Mayer
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Religious Moderation in Practice: A Framing Analysis of Nonformal Hajj Education and Its Global Relevance

Afkaruna: Indonesian Interdisciplinary Journal of Islamic Studies
Religious moderation has emerged as a central discourse in strengthening social cohesion and countering the rise of exclusivist and radical narratives in Muslim-majority societies.
Marsudi, Nina Mariani Noor
doaj   +1 more source

Mortgage Lending and the Great moderation: a multivariate GARCH Approach [PDF]

Financial innovation during the Great Moderation increased the size and scope of credit flows in the US. Credit flows increased both in volume and with regard to the range of activities and investments that was debt-financed. This may have contributed to
Grydaki, Maria, Bezemer, Dirk J
core  

Great Moderation(s) and U.S. Interest Rates: Unconditional Evidence [PDF]

, 2018
The US economy experienced a Great Moderation sometime in the mid-1980s – a fall in the volatility of output growth – at the same time as a fall in both the volatility of inflation and the average rate of inflation.
Nason, James M., Smith, Gregor W.
core   +1 more source