Results 41 to 50 of about 5,460,179 (306)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Muslim Moralists’ Contributions to Moderation Theory in Ethics [PDF]

, 2020
Originally introduced by Plato and Aristotle, Moderation Theory in Ethics is the most prevalent theory of ethics among Islamic scholars. Moderation Theory suggests that every virtue or excellence of character lies in the mean between two vices: excess or
Atrak, Hossein
core   +2 more sources

Devising an impactful religious moderation workshop for teachers and principals: The practice of Ice Berg analysis and U theory perspective

Journal of Community Service and Empowerment
In the academic setting, teachers and school principals are often faced with the problem of identifying and developing strategies to strengthen the atmosphere of religious moderation. Unfortunately, resources for training and support are scarce.
Yusuf Hanafi, Muhammad Saefi, M. Alifudin Ikhsan, Tsania Nur Diyana, Faris Khoirul Anam, Oktaviani Adhi Suciptaningsih   +5 more
doaj   +1 more source

What’s the point of moderation? A discussion of the purposes achieved through contemporary moderation practices [PDF]

, 2015
An increasingly regulated higher education sector is renewing its attention to those activities referred to as ‘moderation’ in its efforts to ensure that judgements of student achievement are based on appropriate standards. Moderation practices conducted
Bloxham, Susan, Bloxham, Sue, Hughes, Clair, Adie, Lenore   +3 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Managing the moderation of school-based assessment at Grade 12 level in Gauteng

Acta Academica, 2013
In 2000, the National Minister of Education mandated the inclusion of school-based assessment (SBA) as a component of the Senior Certificate (Grade 12) assessment.
Bennie Grobler, Coert Loock, Prem Govender   +2 more
doaj   +3 more sources

Proactive Personality and Innovative Work Behavior: Through the Juxtapose of Schumpeter's Theory of Innovation and Broaden-And-Build Theory

Frontiers in Psychology, 2022
This study aimed to unfold the implicit interplay of open innovation (OI) and perceived insider status (PIS) between the relationship of proactive personality (PP) and innovative work behavior (IWB).
Weizheng Li, Shabeeb Ahmad Gill, Yang Wang, Muhammad Adeel Safdar, Muhammad Ramzan Sheikh   +4 more
doaj   +1 more source

The heuristics theory of emotions and moderate rationalism

Philosophical Psychology, 2022
This paper argues that emotions can play an epistemic role as justifiers of evaluative beliefs. It also presents the heuristics theory of emotion as an empirically informed explanation of how emotions can play such a role and why they in practice usefully complement non-affective evaluative judgments. As such, the heuristics theory represents a form of
openaire   +2 more sources

Integrating Mediation and Moderation to Advance Theory Development and Testing [PDF]

Journal of Pediatric Psychology, 2013
The concepts and associated analyses of mediation and moderation are important to the field of psychology. Although pediatric psychologists frequently incorporate mediation and moderation in their theories and empirical research, on few occasions have we integrated mediation and moderation.
Bryan T, Karazsia, Kristoffer S, Berlin, Bridget, Armstrong, David M, Janicke, Katherine E, Darling   +4 more
openaire   +2 more sources