Results 31 to 40 of about 4,115,860 (254)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Modern Şifacılık Yönelimlerinden Enerji Şifacılığı Uygulamaları
Günümüzde modern şifacılık yönelimlerinden enerji şifacılığı uygulamaları yaygınlaşmaktadır. New Age inanışları içerisinde kabul edilen enerji şifacılığı her kesimden insana hitap etmekte ve fizyolojik hastalıklar, kişisel problemler gibi birçok soruna ...
Handan Yalvaç Arıcı
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Long rangers: SLCMs still add reach and strategic impact, Piranha 5: militaries remain hooked on proven platform, Will we ever build more F-22?, Russia's Next Super Submarine Is Almost Ready for War, Joint effort, New BMP-1 upgrade ...
Dragan M. Vučković
doaj +2 more sources
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
KELENTURAN MASYARAKAT BALI-TRADISIONAL TERHADAP MODERNITAS DALAM KUMPULAN CERPEN MANDI API
This study analyzes the social dynamics of Balinese culture and intellectual to face tradition and modernization clash by applying the theory of sociology literaryas a scalpel. This researchis is adescriptive study using descriptive qualitative research,
Puji Retno Hardiningtyas
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New Directions in Digital Modern Languages Research
This Special Collection results from an open call that sought out new and emerging research at the intersection of Modern Languages and digital culture, media, and technologies. The Collection is intentionally wide-ranging and transdisciplinary in focus,
Wells, N. +3 more
core +4 more sources
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source

