Results 51 to 60 of about 3,080,533 (312)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

New modern shorthand; a complete manual of amaneunsis, court and verbatim reporting, [PDF]

open access: yes, 1908
Earlier issue has title: Modern shorthand.Mode of access ...
Modern Publishing Company.   +1 more
core  

Al-Nahda dan Munculnya Aliran-Aliran pada Sastra Arab Modern

open access: yesLinguistika Kultura
Artikel ini bertujuan untuk menguak muculnya berbagai aliran sastra Arab pada masa Al-Nahda berikut fenomena yang melatarbelakanginya. Penelitian ini merupakan penelitian kajian pustika yang menggunakan metode deskriptif analisis.
Insanul Hasan, Ferdinal Ferdinal
doaj   +1 more source

The Expression of Religious Positivity in Karen Armstrong’s Sīrah Work

open access: yesJournal of Islamic and Religious Studies, 2018
Orientalists contributed much regarding their study of the Holy Qur’ān, Hadith and Sīrah since eighteenth century. Few of them attracted Muslim scholars due to the quality of their work about Islam, like the translation of the Holy Qur’ān, the indexes of
Fozia Fiaz, Dr Mohsina Munir
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Ovidian Paratexts: Guiding the reader to the Metamorphoses in the early modern Low Countries [PDF]

open access: yes, 2019
In the Early Modern Period, Ovid's Metamorphoses was a popular text: printers in the sixteenth and seventeenth-century Low Countries printed no fewer than 108 editions.
ICON - Early Modern Literature   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

Modern Products photograph, Paratrooper, circa 1978. [PDF]

open access: yes, 2000
Fred Warwick's Upright Paratrooper - UP28 - photographed as publicity for Modern Products.
Modern Products
core  

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