Results 41 to 50 of about 413,917 (262)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Archaeologia Historica, 2016 Cieľom predloženého príspevku bola dokumentácia zaniknutých cestných reliktov na trase stavby diaľnice D3 Svrčinovec – Skalité, analýza ich tvarov a interpretácia v kultúrno-historickom kontexte.
Marek Vojteček, Adrián Nemergut
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
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Malé Šance a Valy v Čiernom : príspevok k poznaniu pevnostného systému Jablunkovského priesmyku
Archaeologia Historica, 2016 Jablunkovský priesmyk predstavoval strategický bod v uhorsko-sliezskom pohraničí. Snahy o zabezpečenie tohto priestoru začali už v 16. storočí. Počas dvoch storočí tu bol vybudovaný rozsiahly systém samostatných vojenských opevnení rôznych kategórií ...
Marek Vojteček
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Frontiers in Pediatrics, 2020 Background: A crucial aspect of the 2019 coronavirus disease (COVID-19) pandemic was the psychological impact on the population. Most countries issued restrictive laws to reduce community-based viral spread.
Stefano Passanisi +8 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
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Život na hranici města: príspevok k výsledkom archeologického výskumu Vodnej veže
Archaeologia Historica, 2017 Predložená štúdia sa venuje nálezom z výskumu Vodnej veže v Bratislave, ktorý bol realizovaný Mestskou správou pamiatkovej starostlivosti a ochrany prírody (MSPSOP) v 70. a 80. rokoch 20. storočia.
Petra Šimončičová Koóšová +3 more
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
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Historical Consciousness in Youth. Theoretical and Exemplary Empirical Analyses
Forum: Qualitative Social Research, 2001 The thesis that historical consciousness is an anthropological competence and category is called into question. A concept of modern historical consciousness is outlined which from then on serves as a working concept. This kind of historical consciousness,
Carlos Kölbl, Jürgen Straub
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