Results 101 to 110 of about 3,734,042 (289)

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

open access: yesAdvanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang   +10 more
wiley   +1 more source

Analysis of impediments to fair housing choice, 1997 Impediments to fair housing choice Fair housing action plan, 1997-2000

open access: yes, 1997
Table of Contents -- Introduction -- What is Fair Housing? -- What is Prohibited? -- What is Not Covered by the Fair Housing Act? -- Summary of Fair Housing and Related Laws -- Population and Demographic Trends -- Impediments to Fair Housing Choice ...
Kansas Division of Housing
core  

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu   +4 more
wiley   +1 more source

Comprehensive housing affordability strategy

open access: yes, 1992
"In compliance with the Cranston-Gonzalez National Affordable Housing Act of 1990."INTRODUCTION -- CHAS DEVELOPMENT PROCESS -- SECTION ONE: STATE PROFILE -- PART I: MARKET AND INVENTORY CONDITIONS -- REGIONAL PROFILES -- PART 2: NEEDS ASSESSMENT ...
Kansas Department of Commerce, State Office of Housing
core  

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

open access: yesAdvanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer   +12 more
wiley   +1 more source

Housing profile

open access: yes, 1993
Spring 1993Kansas Makes Progress In Housing -- Kansas Housing Market Areas -- Kansas Housing Needs Increase for Low-Income -- Estimated Households Living In Inadequate and Costly Housing in Kansas: 109,000 -- Why Families Can't Afford A House -- Kansas ...
Kansas Division of Housing
core  

Integrating Kinetics into Synthetic Studies via Adaptable Concentration‐Dependent Yield Analysis

open access: yesAdvanced Science, EarlyView.
A method to derive kinetic parameters from synthetic studies was developed and named concentration‐dependent yield analysis (CYAN). Using numerical Euler integration for kinetic regression, CYAN was proven adaptable to chemical and operational considerations and revealed unexpected template effects of a transition metal that mediated competitive ...
Xinyi Xiao   +4 more
wiley   +1 more source

Ev Mimarisinin Aile ve Dini Hayat Açısından Önemi / The Importance of Home Architecture in terms of Family and Religious Life / أهمية العمارة المنزلية للأسرة والحياة الدينية

open access: yesİlahiyat Akademi, 2020
İnsanın barınma arayışı ev ile neticelenmiştir. Ev mimarisi doğal imkânlar kadar toplumun yaşam biçiminden de izler taşır. Bununla beraber evin kendisi de insanı bir hayat tarzına zorlar.
Erol Erkan
doaj  

Housing resources [1997]

open access: yes, 1997
Homeownership -- Rental Housing -- Housing with Supportive Services -- Asset Management -- Information ...
Kansas Division of Housing
core  

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

open access: yesAdvanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami   +7 more
wiley   +1 more source

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