Results 101 to 110 of about 57,308 (297)
Advanced Science, EarlyView.Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong +20 more
wiley +1 more source
Advanced Science, EarlyView.A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang +12 more
wiley +1 more source
The Effects of Critical Habitat Designation on Housing Supply: An Analysis of California Housing Construction Activity [PDF]
Under the Endangered Species Act, the U.S. Fish and Wildlife Service is required to designate critical habitat for listed species. Designation could result in modification to or delay of residential development projects within habitat boundaries ...
Jeffrey E. Zabel, Robert W. Paterson
core
RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine
Advanced Science, EarlyView.RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen +14 more
wiley +1 more source
The role of the architect in post-war state housing : a case study of the housing work of the London County Council, 1919-1956 [PDF]
This research offers a critical history of the rble played by the architect in post Second world war state Housing. It takes the housing output of the London county council, from 1939 to 1956, as a case study.
Day, Nicholas Merthyr
core
Social policy and housing: reflections of social values [PDF]
, 2010 This thesis set out to find the correlation between social values and standards in social housing in two major milestones in the developments in state-provided housing.
Manoochehri, J.
core
Advanced Science, EarlyView.A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker +11 more
wiley +1 more source
İlahiyat Akademi, 2020 İnsanın barınma arayışı ev ile neticelenmiştir. Ev mimarisi doğal imkânlar kadar toplumun yaşam biçiminden de izler taşır. Bununla beraber evin kendisi de insanı bir hayat tarzına zorlar.
Erol Erkan
doaj