Results 151 to 160 of about 1,411,743 (318)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Discriminación visual como determinante de estilo y asignación tipológica de la cerámica códice de Calakmul, Campeche Visual Discrimination as a Style and Typological Classification Determiner for "Codex"Ceramics in Calakmul, Campeche

Estudios de Cultura Maya, 2012
Los aproximadamente 600 fragmentos de cerámica de estilo códice recuperados por el Proyecto Arqueológico Calakmul, corresponderían a un mínimo de 86 vasijas. La mayoría proviene de contextos asociados al palacio, Estructura XX, de la Gran Acrópolis donde,
Sylviane Boucher, Yoly Palomo
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

On the Stability of Mercier and Ballooning Modes in Stellarator Configurations

, 1997
"The stability properties of pressure driven ballooning and Mercier modes in general stellarator configurations are studied. A method originally introduced to study tokamak stability by J.M. Greene and M. S. Chance [Nucl.
Nakajima, N.", "Hegna, C. C.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Spatially tailored spin wave excitation for spurious-free, low-loss magnetostatic wave filters with ultra-wide frequency tunability. [PDF]

Microsyst Nanoeng
Wu S, Yao S, Du X, Chang CY, Olsson RH.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Les modes alternatifs de règlement de litiges

, 2019
La nouvelle édition de la table-ronde du Centre de recherches administratives de la Faculté de droit et de science politique d’Aix-en-Provence porte sur les « modes alternatifs de règlement des litiges » dans le champ du droit administratif, du point de ...
La table ronde de droit administratif comparé : Les modes alternatifs de règlement de litiges, Renders, David   +1 more
core  

Koopman mode decomposition of thermodynamic dissipation in nonlinear Langevin dynamics. [PDF]

Proc Natl Acad Sci U S A
Sekizawa D, Ito S, Oizumi M.
europepmc   +1 more source