Results 121 to 130 of about 4,784,459 (323)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Forest and Land Fire Vulnerability Mapping Based on Land Physical Parameters in Sumatera and Kalimantan Region of Indonesia

open access: yesJournal of Applied Geospatial Information, 2017
Indonesia is a country that has vulnerablity to land and forest fires danger. This is not out of the existencies of peatland in Indonesia which are quite wide and mostly located in Sumatara and Kalimantan.
Ardila Yananto   +2 more
doaj  

Study of structural, surface energies, and tribomechanical properties of thermoplastics irradiated by electron beam

open access: yesMaterials Research Express
This study investigates the effects of electron irradiation on the structural, surface energy, and tribomechanical properties of two key thermoplastics: polyetheretherketone (PEEK) and polytetrafluoroethylene (PTFE).
Bauyrzhan Rakhadilov   +5 more
doaj   +1 more source

Scavenging effect analysis of precipitation on PM2.5 and PM10 in Sichuan Basin

open access: yes暴雨灾害
The Sichuan Basin is one of the most severely air-polluted regions in China. To study the scavenging effect of precipitation on PM2.5 and PM10 in Sichuan Basin, the PM2.5 and PM10 mass concentration data from 90 environmental monitoring stations and ...
Sasa ZHENG   +3 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Microphysical Characteristics of Melting Layers in North China Revealed by Aircraft and Radar

open access: yesRemote Sensing
The microphysical processes within the melting layer (ML) of stratiform clouds have been understudied, particularly regarding their intricate properties and behaviors.
Xiangfeng Hu   +8 more
doaj   +1 more source

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