Results 141 to 150 of about 2,014,406 (292)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

2'-hydroxyl modification improves enzymatic and thermal stability of mRNA. [PDF]

Mol Ther Nucleic Acids
Uchida S.
europepmc   +1 more source

Modification of the clozapine structure by parallel synthesis

, 2006
Jing Su, Haiqun Tang, Brian A. McKittrick, Duane A. Burnett, Hongtao Zhang, April Smith‐Torhan, Ahmad Fawzi, Jean E. Lachowicz   +7 more
openalex   +1 more source

Implementation and modification of a service model for community transitional rehabilitation for people with acquired brain injury

, 2023
Mandy Nielsen, Kerrin Watter, Jaycie K. Bohan, Areti Kennedy   +3 more
openalex   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimizing Surface Functionalization for Aptameric Graphene Nanosensors in Undiluted Physiological Media. [PDF]

Sensors (Basel)
Dai W, Wang Z, Yu S, Wen K, Yang Y, Lin Q.   +5 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology. [PDF]

Cell Death Dis
Wang H, Zhang J, Jiang C, Xu S.
europepmc   +1 more source

Modifications to synaptic transmission at group Ia synapses on cat spinal motoneurones by 4‐aminopyridine. [PDF]

, 1981
Julian Jack, Stephen Redman, Ken C. L. Wong   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source