Results 201 to 210 of about 1,777,350 (269)

Enhancing targeted strategies for cancer immunotherapy by elucidating mRNA processing mechanisms. [PDF]

Front Immunol
Lu X, Gan W, Yuan J, Chen Z.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Single-base resolution atlas reveals moderate conservation and regulatory diversity of m6A modifications across mammals. [PDF]

Nucleic Acids Res
Zhang X, Zhang Z, Liu W, Liu W, Li M, Chen W, Liu G, Dai Y, Li Z, Hu C, Pan Q, Yu Y, Liu X, Zhu P, Zhou X.   +14 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Rheological characteristics and modification mechanism of rock asphalt compound modified binder based on grey relational analysis. [PDF]

PLoS One
Hou J, Guo X.
europepmc   +1 more source

RNA modifications in cancer and their detection: a review. [PDF]

Jpn J Clin Oncol
Yu BY, Ueda H.
europepmc   +1 more source

Thio-modification effects on mRNA translation using a PureCap-based capping method. [PDF]

RSC Chem Biol
Meng Z, Liu Y, Nakashima Y, Inagaki M, Kimura S, Kondo Y, Hashiya F, Abe N, Saito-Tarashima N, Minakawa N, Kimura Y, Abe H.   +11 more
europepmc   +1 more source

Combining Phenolization Treatment with the Mannich Reaction for Modification of Kraft Lignin to Produce Highly Efficient Lignin-Based Nitrogen Fertilizer. [PDF]

Polymers (Basel)
Mo X, Wang Y, Tian Z, Ji X, Zhang F, Zhou J.   +5 more
europepmc   +1 more source

Modifying implementation strategies for integration of screening and management of mental disorders, including substance use disorders into other NCD care in Faridabad, Haryana as part of ICMR-MINDS project. [PDF]

Front Public Health
Balhara YPS, Dahiya N, Chhatbar T, Bhardwaj P, Sarkar S, Verma H, Singh K, Atri G, Saini OPS, Verma P, Grover A.   +10 more
europepmc   +1 more source