Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Epigenetic modification mechanism of histone demethylase KDM1A in regulating cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury. [PDF]
PeerJ, 2022 He L, Wang Y, Luo J.
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Plastic surface modification : surface treatment and adhesion /
, 2010 "The aim of this book is to describe the primary polymer adhesion issues faced by manufacturers, processors and converters, to outline a variety of methods for attaining an appropriately activated surface, and to provide the diagnostics for various ...
Wolf, Rory A.
core
N6-methyladenosine modification in ischemic stroke: Functions, regulation, and therapeutic potential
HeliyonN6-methyladenosine (m6A) modification is the most frequently occurring internal modification in eukaryotic RNAs. By modulating various aspects of the RNA life cycle, it has been implicated in a wide range of pathological and physiological processes ...
Fei Han
doaj +1 more source
Modification Mechanism and Rheological Properties of Emulsified Asphalt Evaporative Residues Reinforced by Coupling-Modified Fiber. [PDF]
Materials (Basel), 2021 Lu Z +6 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory. [PDF]
Elife, 2021 Lövkvist C +5 more
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Antikythera Mechanism PTMs brightened 35-42, Fragment B
, 2019 These PTMs were constructed from images of all known remaining surfaces of the Antikythera Mechanism fragments housed in the National Archaeological Museum in Athens, Greece.
Antikythera Mechanism Research Project
core +13 more sources