Results 141 to 150 of about 948,465 (312)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

On the mechanism of the Shapiro reaction: Understanding the regioselectivity

open access: yes, 2015
A detailed DFT-level mechanism elucidation of the two-step reaction of tosylhydrazones with alkyllithium reagents (the Shapiro reaction) is presented.
Funes-Ardoiz, I. [0000-0002-5843-9660]   +2 more
core   +1 more source

Functions and mechanism of modification elements in eutectic solidification of Al-Si alloys: A brief review

open access: yes, 2014
Being used more and more widely in engineering, Al-Si alloys comprise about 80% of all kinds of aluminum alloys, which are the most widely utilized nonferrous alloys.
Li Xiaoyun, Zu Fangqiu
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Efficient removal of imazethapyr from aqueous solution by Fe–Mg modified biochar: Performance, mechanism and applicability

open access: yesChemical Engineering Journal Advances
Given the persistent environmental and non-target organismal threats posed by imazethapyr, there is an urgent need to develop an efficient adsorbent material for the removal of residual imazethapyr.
Qingqing Fan   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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