Results 211 to 220 of about 4,554,323 (351)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modification mechanism of Te and morphology evolution of primary Mg₂Si in an Al-20Mg₂Si alloy. [PDF]

Heliyon
Li C, Wang Z, Zhao Y, Du J, Ma Y, Li J, Sun F.   +6 more
europepmc   +1 more source

Study of the modification mechanism of heavy metal ions adsorbed by biomass-activated carbon doped with a solid nitrogen source. [PDF]

RSC Adv, 2019
Zheng W, Chen S, Liu H, Ma Y, Xu W.
europepmc   +1 more source

Femtosecond laser surface modification of silicon carbide: A review of interaction mechanisms, structural regulation, and functional applications

Aoyu Guo, Jieshi Chen, Wenwen Jia, Jie Li, Yiang Yang, Zhichang Yang, Hao Lu, Lihui Song   +7 more
openalex   +1 more source

Mechanisms and applications of plasma-induced surface modification for improving the electrical properties of silicone rubber [PDF]

Zhihua Qi, Zhiliang Wang, Chuxiao Sun, Guangyi Meng, Jiao Zhang, Wangwen Xu, Dong Zhang, Chao Zhang, Shaohua Zhang, Zheng Zhang   +9 more
openalex   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

iCMMT 2024

Chinese Society of Mechanism and Machine Theory
core   +1 more source

Study on the Hydrophobic Modification Mechanism of Stearic Acid on the Surface of Coal Gasification Fly Ash. [PDF]

Molecules
Yang J, Li L, Wang W.
europepmc   +1 more source

A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate. [PDF]

IUCrJ, 2019
Park SH, Suh SW, Song HK.
europepmc   +1 more source

Thermodynamic mechanism of non-metallic inclusions modification in recycled low-alloyed cast steel using CaCO₃–CaSiO₃ composite mineral fluxes

Nozimjon Kholmirzaev, Nodir Turakhodjaev, Jamshidbek Khasanov, Abdujalol Bektemirov, Nosir Saidmakhamadov, Zokirjon Nurdinov, Shovkat Tursunov, Shakhzodjon Turdiev, Rustam Parpiev, Farkhad Maksumov, Dilshod Sartibayev, Камолиддин Хасанов   +11 more
openalex   +2 more sources