Results 81 to 90 of about 948,465 (312)
To enhance the high and low-temperature performance of asphalt materials and extend the service life of asphalt pavement, two types of external admixtures, Butonite rock asphalt, and nano-silica are added to the asphalt.
Zhenxia Li +6 more
core +1 more source
Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism
Neurobiology of Disease, 2015 Neuroferritinopathy is a rare, late-onset, dominantly inherited movement disorder caused by mutations in L-ferritin gene. It is characterized by iron and ferritin aggregate accumulation in brain, normal or low serum ferritin levels and high variable ...
Sonia Levi, Ermanna Rovida
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]
, 2014 O-GlcNAc signalling is regulated by an opposing pair of enzymes: O-GlcNAc transferase (OGT) instals, and O-GlcNAcase (OGA) removes the modification from proteins.
van Aalten, Daan M. F. +4 more
core +1 more source
NanomaterialsThis study employed a dry-process method to prepare SBS/recycled LDPE/EVA composite-modified particles (CMP) for asphalt mixture modification. Conventional performance tests, including penetration tests, determined the optimal CMP dosage to be 8% by mass
Zhengwei Yi +7 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Meikuang AnquanThe existing inorganic spray air leakage sealing materials are prone to cracking and forming air leakage cracks. Modifying the fibers containing non-polar groups and adding them to cement-based materials can effectively reduce the occurrence of air ...
Chunxia WANG
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mechanisms of Histone Modifications
, 2022 In eukaryotic genomes, DNA is condensed in the form of chromatin. While chromatin is fundamentally a protective structure, it constitutes a challenge for all major cellular functions, for which interaction with the DNA sequence is a necessary requirement.
openaire +1 more source