Results 101 to 110 of about 4,554,323 (351)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Food Chemistry: XWheat is one of major human staple foods, contributing an important source of dietary protein. However, some people are allergic to wheat-based foods.
Nan Jiang +5 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Mechanism of Cholesterol Modification of Hedgehog Ligand
Journal of Computational Chemistry, 2019 Hedgehog (Hh) proteins are important components of signal transduction pathways involved in animal development, and their defects are implicated in carcinogenesis. Their N‐terminal domain (HhN) acts as a signaling ligand, and their C‐terminal domain (HhC) performs an autocatalytic function of cleaving itself away, while adding a cholesterol moiety to ...
openaire +4 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Antikythera Mechanism PTMs 21-34, Fragment C
, 2019 These PTMs were constructed from images of all known remaining surfaces of the Antikythera Mechanism fragments housed in the National Archaeological Museum in Athens, Greece.
Antikythera Mechanism Research Project
core +15 more sources
To enhance the high and low-temperature performance of asphalt materials and extend the service life of asphalt pavement, two types of external admixtures, Butonite rock asphalt, and nano-silica are added to the asphalt.
Zhenxia Li +6 more
core +1 more source
Combining play therapy with behavior modification in child counseling [PDF]
, 2004 Plan BThe purpose of this study was to identify how child therapists perceive and utilize both behavior modification and play therapy. Sixty surveys were sent to child therapists in Wisconsin.
Lisec, Sara J.
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source