Results 51 to 60 of about 575,797 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Approximation of Integrable Functions by Modified Barbosu Operators [PDF]

open access: yesInternational Journal of Mathematical, Engineering and Management Sciences
This paper presents an approximation method of integrable functions using a modified Barbosu operator, aimed at improving the rate of convergence in function approximation on the interval [0,1]. By introducing a suitable adjustment in the weight function,
Rahul Kumar, Asha Ram Gairola
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Local polynomial method for frequency response function identification

open access: yesSystems Science & Control Engineering, 2020
Here we propose the local polynomial method to solve the problem of estimating the frequency response function in the linear system. Compared with other nonparametric identification methods based on the windowing strategies, this new identification ...
Dong Xiguang   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

A Proposed Method For Selecting The Clustering Algorithm In Radial Basis Function [QA223. A581 2008 f rb]. [PDF]

open access: yes, 2008
Rangkaian Fungsi Asas Radial telah digunakan dengan meluas untuk menganggarkan dan mengelaskan data. Model biasa bagi Fungsi Asas Radial menentukan pusat, Radial Basis Function Networks have been widely used to approximate data and classify data.
Ang, Sau Loong
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

天文望远镜传动直齿轮齿廓修形设计

open access: yesJixie chuandong, 2010
Adopted high-order power function and short modification as the profile modification mode of spur gears used in astronomical telescopes,it can meet the necessity of the contact ratio and improve the static transmission error,and avoid stress ...
冯锦平, 马文礼
doaj  

An accurate relationship between frequency and amplitude to nonlinear oscillations

open access: yesJournal of Taibah University for Science, 2018
A weighted global error minimization (WGEM) is proposed in this study. The goal is to improve the accuracy of the global error minimization (GEM) based on a weighting function.
M. K. Yazdi
doaj   +1 more source

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