Results 221 to 230 of about 8,885,090 (257)
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2007
Lamotrigine exhibits an anti-immobility effect in the modified forced swimming test, increasing swimming and climbing, behaviors that are related to serotonergic and noradrenergic effects, respectively. However, these effects could be secondary to lamotrigine blockade of Na(+) sensitive channel. Thus, this study investigated the influence of veratrine (
Ana Lúcia S Rodrigues +2 more
exaly +3 more sources
Lamotrigine exhibits an anti-immobility effect in the modified forced swimming test, increasing swimming and climbing, behaviors that are related to serotonergic and noradrenergic effects, respectively. However, these effects could be secondary to lamotrigine blockade of Na(+) sensitive channel. Thus, this study investigated the influence of veratrine (
Ana Lúcia S Rodrigues +2 more
exaly +3 more sources
Effect of Thioperamide on Modified Forced Swimming Test-Induced Oxidative Stress in Mice [PDF]
Basic and Clinical Pharmacology and Toxicology, 2005 Abstract: This study was designed i) to investigate the role of histamine H3‐receptor ligands on mouse modified forced swimming test, a method that distinguishes the catecholaminergic behaviour with that of serotonergic compounds and ii) to evaluate the role of free radicals in mediation of such effects.
Mohd Akhtar, Divya Vohora, K K Pillai
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Neuroscience and Biobehavioral Reviews, 2005
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressant class today and exert their antidepressant-like effects by increasing synaptic concentrations of serotonin (5-HT). The rat forced swim test (FST) is the most widely used animal test predictive of antidepressant action.
John F. Cryan +2 more
exaly +3 more sources
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressant class today and exert their antidepressant-like effects by increasing synaptic concentrations of serotonin (5-HT). The rat forced swim test (FST) is the most widely used animal test predictive of antidepressant action.
John F. Cryan +2 more
exaly +3 more sources
Orchiectomy modifies the antidepressant-like response of nicotine in the forced swimming test
Physiology & Behavior, 2010Several studies have demonstrated that nicotine (NIC) exhibits antidepressant-like effects. In addition, it has been suggested that sexual hormones participate in the antidepressant actions of antidepressives. The present study was designed to analyze the effect of orchiectomy and the supplementation of testosterone propionate (TP) or 17β-estradiol (E ...
H, Bonilla-Jaime +6 more
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The modified forced-swim test in rats: Influence of rope- or straw-suspension on climbing behavior
Physiology & Behavior, 1988We modified Porsolt's forced-swim test by suspending ropes or straws above the water in order to investigate a possible relationship between immobility and perceived escape responses from water. In this modified test, it was demonstrated clearly that rats reduced their duration of immobility and attempted to climb up the suspended ropes or straws. Most
H, Nishimura +3 more
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European Neuropsychopharmacology, 2006
Lamotrigine is an anticonvulsant drug that exhibits a clinical antidepressant effect. However, few studies have been conducted with lamotrigine in animal models of depression and its mechanism of antidepressant action is still unclear. The present study evaluates the effect of lamotrigine (5-20mg/kg, i.p.) in the modified forced swimming test and ...
Fernando T, Consoni +2 more
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Lamotrigine is an anticonvulsant drug that exhibits a clinical antidepressant effect. However, few studies have been conducted with lamotrigine in animal models of depression and its mechanism of antidepressant action is still unclear. The present study evaluates the effect of lamotrigine (5-20mg/kg, i.p.) in the modified forced swimming test and ...
Fernando T, Consoni +2 more
openaire +2 more sources
European Journal of Pharmacology, 2002
The novel antidepressant reboxetine is a selective norepinephrine reuptake inhibitor. In this study, the antidepressant-like effects of reboxetine were characterized in a modified rat forced swim test. Further, in order to investigate the role of the locus coeruleus and lateral tegmental noradrenergic systems in the mediation of reboxetine's effects ...
John F, Cryan +2 more
openaire +2 more sources
The novel antidepressant reboxetine is a selective norepinephrine reuptake inhibitor. In this study, the antidepressant-like effects of reboxetine were characterized in a modified rat forced swim test. Further, in order to investigate the role of the locus coeruleus and lateral tegmental noradrenergic systems in the mediation of reboxetine's effects ...
John F, Cryan +2 more
openaire +2 more sources
Pharmacology Biochemistry and Behavior, 1992
The present study was undertaken to examine how the triazolobenzodiazepine derivative, alprazolam, which possesses anxiolytic activity in man and anticonflict effects in animals, could affect both the duration of immobility and the incidence of straw-climbing behavior of rats in a modified forced-swim (MFS) test.
H, Nishimura, M, Tanaka
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The present study was undertaken to examine how the triazolobenzodiazepine derivative, alprazolam, which possesses anxiolytic activity in man and anticonflict effects in animals, could affect both the duration of immobility and the incidence of straw-climbing behavior of rats in a modified forced-swim (MFS) test.
H, Nishimura, M, Tanaka
openaire +2 more sources
Pharmacology Biochemistry and Behavior, 2001
Recent findings have demonstrated that Fawn hooded (FH/Har) rats exhibit enhanced plasma corticosterone (CORT) responses compared to Wistar rats after exposure to an open field, whereas this effect was not influenced by early social experience. In contrast, it was found that behavior in a modified version of the Porsolt Forced Swim Test (Porsolt FST ...
F S, Hall +3 more
openaire +2 more sources
Recent findings have demonstrated that Fawn hooded (FH/Har) rats exhibit enhanced plasma corticosterone (CORT) responses compared to Wistar rats after exposure to an open field, whereas this effect was not influenced by early social experience. In contrast, it was found that behavior in a modified version of the Porsolt Forced Swim Test (Porsolt FST ...
F S, Hall +3 more
openaire +2 more sources