Results 91 to 100 of about 682,094 (268)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PERFORMANCE ANALYSIS OF METHODS FOR ESTIMATING WEIBULL PARAMETERS FOR WIND SPEED DISTRIBUTION IN THE DISTRICT OF MAROUA [PDF]

Journal of Fundamental and Applied Sciences, 2014
In this study, five numerical Weibull distribution methods, namely, the maximum likelihood method, the modified maximum likelihood method (MLM), the energy pattern factor method (EPF), the graphical method (GM), and the empirical method (EM) were ...
D. Kidmo Kaoga, R. Danwe, S. Doka Yamigno, N. Djongyang   +3 more
doaj  

Odds Ratios Estimation of Rare Event in Binomial Distribution

Journal of Probability and Statistics, 2016
We introduce the new estimator of odds ratios in rare events using Empirical Bayes method in two independent binomial distributions. We compare the proposed estimates of odds ratios with two estimators, modified maximum likelihood estimator (MMLE) and ...
Kobkun Raweesawat, Yupaporn Areepong, Katechan Jampachaisri, Saowanit Sukparungsee   +3 more
doaj   +1 more source

Generalized Secant Hyperbolic and a Method of Estimate of its Parameters: Maximum Likelihood Modified

, 2013
Se desarrollan diferentes distribuciones generalizadas en la literatura estadística, entre ellas está la distribución hiperbólica secante generalizada (SHG). Este artículo presenta un método alternativo para estimar los parámetros de población del SHG, llamado Probabilidad Máxima Modificada (MVM).
Másmela Caita, Luis Alejandro, Burbano Moreno, Álvaro Alexander   +1 more
openaire   +1 more source

Stimulated Maximum Likelihood Estimation of Continuous Time Stochastic Volatility Models [PDF]

In this paper we develop and implement a method for maximum simulated likelihood estimation of the continuous time stochastic volatility model with the constant elasticity of volatility.
Hans J. SKAUG, Jun YU, Tore Selland KLEPPE   +2 more
core  

Simulation and Robust Modifications of Estimates in Branching Processes [PDF]

, 2004
This study is focused on the comparison and modification of different estimates arising in the branching processes. Simulations of models with or without migration are put through.
Atanasov, D., Stoimenova, V., Yanev, N.
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Bayesian Estimation of Mixed Multinomial Logit Models: Advances and Simulation-Based Evaluations

, 2019
Variational Bayes (VB) methods have emerged as a fast and computationally-efficient alternative to Markov chain Monte Carlo (MCMC) methods for scalable Bayesian estimation of mixed multinomial logit (MMNL) models.
Bansal, Prateek, Bierlaire, Michel, Daziano, Ricardo A., Krueger, Rico, Rashidi, Taha H.   +4 more
core   +1 more source