Results 91 to 100 of about 683,039 (264)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PERFORMANCE ANALYSIS OF METHODS FOR ESTIMATING WEIBULL PARAMETERS FOR WIND SPEED DISTRIBUTION IN THE DISTRICT OF MAROUA [PDF]
Journal of Fundamental and Applied Sciences, 2014 In this study, five numerical Weibull distribution methods, namely, the maximum likelihood method, the modified maximum likelihood method (MLM), the energy pattern factor method (EPF), the graphical method (GM), and the empirical method (EM) were ...
D. Kidmo Kaoga +3 more
doaj
Odds Ratios Estimation of Rare Event in Binomial Distribution
Journal of Probability and Statistics, 2016 We introduce the new estimator of odds ratios in rare events using Empirical Bayes method in two independent binomial distributions. We compare the proposed estimates of odds ratios with two estimators, modified maximum likelihood estimator (MMLE) and ...
Kobkun Raweesawat +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2013 Se desarrollan diferentes distribuciones generalizadas en la literatura estadística, entre ellas está la distribución hiperbólica secante generalizada (SHG). Este artículo presenta un método alternativo para estimar los parámetros de población del SHG, llamado Probabilidad Máxima Modificada (MVM).
Másmela Caita, Luis Alejandro +1 more
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
2D Reconstruction of Small Intestine's Interior Wall
, 2018 Examining and interpreting of a large number of wireless endoscopic images from the gastrointestinal tract is a tiresome task for physicians. A practical solution is to automatically construct a two dimensional representation of the gastrointestinal ...
Attar, Rahman +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Stimulated Maximum Likelihood Estimation of Continuous Time Stochastic Volatility Models [PDF]
In this paper we develop and implement a method for maximum simulated likelihood estimation of the continuous time stochastic volatility model with the constant elasticity of volatility.
Hans J. SKAUG +2 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source