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Maximum kernel likelihood estimation [PDF]
, 2008 We introduce an estimator for the population mean based on maximizing likelihoods formed by parameterizing a kernel density estimate. Due to these origins, we have dubbed the estimator the maximum kernel likelihood estimate (mkle). A speedy computational
Jaki, Thomas, West, R. Webster
core +4 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Statistical Properties and Applications of the Discrete Exponentiated Modified Topp-Leone Chen Distribution [PDF]
مجلة العلوم التجارية والبيئيةIn this paper, a new distribution with four parameters named discrete exponentiated modified Topp-Leone Chen distribution is introduced, using the general approach of discretization. The discrete exponentiated modified Topp-Leone Chen distribution can be
Abeer Abd EL-Hady +2 more
doaj +1 more source
Entropy, 2023 In this article, we propose a modified multiplicative thinning-based integer-valued autoregressive conditional heteroscedasticity model and use the saddlepoint maximum likelihood estimation (SPMLE) method to estimate parameters.
Yue Xu, Qi Li, Fukang Zhu
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Energy ReportsWind energy, a key renewable source, requires an accurate assessment of its resources, where the Weibull distribution stands out for its ability to model wind variability.
J. Jafet Cruz-Estudillo +4 more
doaj +1 more source
On Finite Mixtures of Modified Intervened Poisson Distribution And Its Applications [PDF]
Journal of Statistical Theory and Applications (JSTA), 2014 Kumar and Shibu proposed a modified version of intervened Poisson distribution (IPD), namely the modified intervened Poisson distribution (MIPD) for tackling situations of further interventions useful for certain practical problems. Here we consider some
C. Satheesh Kumar, D.S. Shibu
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Psych, 2021 There is some debate in the psychometric literature about item parameter estimation in multistage designs. It is occasionally argued that the conditional maximum likelihood (CML) method is superior to the marginal maximum likelihood method (MML) because ...
Jan Steinfeld, Alexander Robitzsch
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source