Results 51 to 60 of about 15,363,485 (274)

INTERVAL ESTIMATION OF WEIBULL DISTRIBUTION BASED ON MODIFIED PIVOTAL VARIABLE METHOD (MT)

Jixie qiangdu, 2023
To solve the problems of complex calculation and weak applicability of the traditional interval estimation methods such as Weibull distribution with the different parameters, a simple interval estimation method suitable to the conditions of multi ...
XUE GuangMing, NING Peng, FU YaoYu, HE HongRui, ZHOU Jun   +4 more
doaj  

The Modified Beta Gompertz Distribution: Theory and Applications

Mathematics, 2018
In this paper, we introduce a new continuous probability distribution with five parameters called the modified beta Gompertz distribution. It is derived from the modified beta generator proposed by Nadarajah, Teimouri and Shih (2014) and the Gompertz ...
Ibrahim Elbatal, Farrukh Jamal, Christophe Chesneau, Mohammed Elgarhy, Sharifah Alrajhi   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Statistical Properties and Applications of the Discrete Exponentiated Modified Topp-Leone Chen Distribution [PDF]

مجلة العلوم التجارية والبيئية
In this paper, a new distribution with four parameters named discrete exponentiated modified Topp-Leone Chen distribution is introduced, using the general approach of discretization. The discrete exponentiated modified Topp-Leone Chen distribution can be
Abeer Abd EL-Hady, Abeer EL-Helbawy, Mai Hegazy   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Modified Multiplicative Thinning-Based INARCH Model: Properties, Saddlepoint Maximum Likelihood Estimation, and Application

Entropy, 2023
In this article, we propose a modified multiplicative thinning-based integer-valued autoregressive conditional heteroscedasticity model and use the saddlepoint maximum likelihood estimation (SPMLE) method to estimate parameters.
Yue Xu, Qi Li, Fukang Zhu
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Comparative analysis of Weibull parameter estimation methods for wind resource assessment: A case study in Mexico

Energy Reports
Wind energy, a key renewable source, requires an accurate assessment of its resources, where the Weibull distribution stands out for its ability to model wind variability.
J. Jafet Cruz-Estudillo, Edson Nicolás-Balderas, J. Pablo Arenas-López, Alejandro Villegas-Ortega, Mohamed Badaoui   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source