Results 151 to 160 of about 32,167 (256)

Optimization of Fluorescent Nanoparticles Architecture for Efficient Brightness, FRET Efficiency and Biosensing

open access: yesSmall Methods, EarlyView.
Architecturally controlled fluorescent polymer nanoparticles spatially confine BODIPY dyes within core‐shell‐crown compartments, enabling independent tuning of brightness and FRET efficiency. Core‐localized dyes maximize brightness, while shell positioning enhances energy transfer.
Dalel El Marrouki   +4 more
wiley   +1 more source

Efficiency comparison between new single‐needle dialysis and conventional double‐needle dialysis and exploration of the optimal prescription parameters for single‐needle hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 419-427, June 2025.
Abstract Objective To compare the dialysis efficiency parameters between new single‐needle dialysis and conventional double‐needle dialysis and to explore the optimal prescription parameters for single‐needle hemodialysis. Methods This study involved a prospective, cross‐over design. Eight patients were randomly divided into two cohorts, which received
Bin Zhao   +8 more
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

open access: yesBrain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová   +19 more
wiley   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

open access: yesCancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima   +6 more
wiley   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

open access: yesThe FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami   +6 more
wiley   +1 more source

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