Results 91 to 100 of about 1,143,409 (289)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Modular hyperbolas

open access: yesJapanese Journal of Mathematics, 2012
We give a survey of a variety of recent results about the distribution and some geometric properties of points $(x,y)$ on modular hyperbolas $xy \equiv a \pmod m$. We also outline a very diverse range of applications of such results, discuss multivariate generalisations and suggest a number of open problems of different levels of difficulty.
openaire   +3 more sources

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Post-Workshop Report for Plug-N-Harvest Modular Façade Retrofit Workshop on Sustainable Places 2019

open access: yesProceedings, 2019
As part of the European Commission Horizon 2020 Plug-N-Harvest project consortium, authors hosted a 90-minute workshop to discuss issues related the modular façade retrofit development in Europe on Sustainable Places 2019 conference at Cagliari ...
Hu Du   +3 more
doaj   +1 more source

On Modular Computation [PDF]

open access: yesMathematics of Computation, 1961
It will be assumed that the reader is familiar w,ith the elementary theory of congruences [1]. Let in, M2, ... *, mn be s integers relatively prime in pairs and let Ml =MIM2 im8. Let xl, x2, * * , x8be an ordered set of s integers such that 0 < xi < mi.
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Metal-rubber Bushing Test Research for Railway Vehicle

open access: yes机车电传动, 2012
To settle the hard technical problem of test device rapid preparation and a mass of repeated detecting tests in metal-rubber bushing R&D for railway vehicle, a modular test device parameter design method based on PROE/EXCEL was presented.
PENG Li-qun   +4 more
doaj  

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