Results 71 to 80 of about 497,890 (298)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Journal of High Energy Physics, 2019 AbstractWe find and propose an explanation for a large variety of modularity-related symmetries in problems of 3-manifold topology and physics of 3d$$ \mathcal{N} $$N= 2 theories where such structuresa prioriare not manifest. These modular structures include: mock modular forms, SL(2,ℤ) Weil representations, quantum modular forms, non-semisimple ...
Cheng, M.CN. +4 more
openaire +6 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
DiagnosticsBackground/Objectives: Arboviruses including dengue virus (DENV), Zika virus (ZIKV), chikungunya virus (CHIKV), yellow fever virus (YFV), and West Nile virus (WNV) co-circulate across the Americas, generating overlapping febrile syndromes that challenge ...
Stephany Young Yusty +8 more
doaj +1 more source
ARTEKS : Jurnal Teknik Arsitektur, 2019 Surabaya adalah kota dengan populasi terpadat kedua di Indonesia. Jumlah populasi yang terus meningkat bersamaan dengan kurangnya jumlah perumahan menengah kebawah menciptakan masalah.
Wisnu A. Sanjaya +1 more
doaj +1 more source
Modular feature selection using relative importance factors [PDF]
, 2004 Feature selection plays an important role in finding relevant or irrelevant features in classification. Genetic algorithms (GAs) have been used as conventional methods for classifiers to adaptively evolve solutions for classification problems.
Li, P, Guan, SU, Zhu, F
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A Modular, Reconfigurable Mold for a Soft Robotic Gripper Design Activity
Frontiers in Robotics and AI, 2017 Soft robotics is an emerging field with strong potential to serve as an educational tool due to its advantages such as low costs and shallow learning curves.
Jiawei Zhang +6 more
doaj +1 more source