Results 51 to 60 of about 1,143,409 (289)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Frontiers in Microbiology, 2015 A method for the extraction of nucleic acids from a wide range of environmental samples was developed. This method consists of several modules, which can be individually modified to maximize yields in extractions of DNA and RNA or separations of DNA ...
Mark Alexander Lever +6 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Experimental Control of Two Connected Fixed Wing Aircraft
Aerospace, 2018 This paper investigates the design and flight test of two fixed wing aircraft connected at the wing tips. Connecting multiple aircraft introduces flexible modes into a typically rigid body system.
Collin Carithers, Carlos Montalvo
doaj +1 more source
Discrete (Two-State) Modular Hyper-Redundant Planar Manipulator
Computer Assisted Methods in Engineering and Science, 2022 This paper presents a concept of an extremely simple planar manipulator composed of 24 congruent modules. Each module has only two possible discrete positions in relation to the previous module: left (-π/6) or right (π/6).
Ela Zawidzka, Machi Zawidzki
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
DrugDiff: small molecule diffusion model with flexible guidance towards molecular properties
Journal of CheminformaticsWith the cost/yield-ratio of drug development becoming increasingly unfavourable, recent work has explored machine learning to accelerate early stages of the development process. Given the current success of deep generative models across domains, we here
Marie Oestreich +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
State-of the-art and future perspective in co-culture systems for tendon engineering
Biomaterials and BiosystemsTendon is a connective tissue that links bone to muscle, allowing for maintenance of skeleton posture, joint movement, energy storage and transmission of muscle force to bone.
Salomé Guillaumin +2 more
doaj +1 more source
IEEE Access, 2022 The aeronautical industry is one of the last groups which has decided to join the distributed architecture trend in order to increase both the safety and efficiency of future aircraft.
Gaizka Martinez +4 more
doaj +1 more source