Results 31 to 40 of about 202,716 (219)

Small-Signal Modeling and Interaction Analysis of LCC-HVDC Systems Based on Harmonic State Space Theory

IEEE Access, 2022
High-voltage direct current (HVDC) technology based on Line Commutated Converter (LCC) is widely used in modern power systems due to its numerous benefits.
Kezheng Jiang, Pan Hu, Kan Cao, Dan Liu, Chang Ye   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparison on the Effectiveness of Modular Learning in General Mathematics among the Senior High School Strands

Southeast Asian Mathematics Education Journal, 2021
This study aimed to compare the effectiveness of modular learning among senior high school strands and investigate the influence of students’ demographic profiles on their academic performances.
Imee Borinaga Gutierrez
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

DrugDiff: small molecule diffusion model with flexible guidance towards molecular properties

Journal of Cheminformatics
With the cost/yield-ratio of drug development becoming increasingly unfavourable, recent work has explored machine learning to accelerate early stages of the development process. Given the current success of deep generative models across domains, we here
Marie Oestreich, Erinc Merdivan, Michael Lee, Joachim L. Schultze, Marie Piraud, Matthias Becker   +5 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

State-of the-art and future perspective in co-culture systems for tendon engineering

Biomaterials and Biosystems
Tendon is a connective tissue that links bone to muscle, allowing for maintenance of skeleton posture, joint movement, energy storage and transmission of muscle force to bone.
Salomé Guillaumin, Andrea Rossoni, Dimitrios Zeugolis   +2 more
doaj   +1 more source

Turismo de bienestar como segmento en crecimiento: una mirada desde los estudios bibliométricos

Rehuso, 2023
El turismo de bienestar se ha convertido en los últimos años en una industria de gran desarrollo económico a nivel mundial. Actualmente, se ha incrementado el número de personas que buscan un estilo de vida saludable, propiciando el crecimiento de viajes
Jéssica-María de la Cruz-Piña, Reynold Ferrero-Ronda, José Ricardo Rivas-Nuila, Nolberto Cruz-Aguilera   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source