Results 41 to 50 of about 3,824 (290)
Building modular motor complexes [PDF]
Journal of Cell Biology, 2014 ![Figure][1] A kymograph shows the velocity of kinesin-1/kinesin-3 complexes (yellow) compared with individual kinesin-1 (green) and kinesin-3 (red) motors in vitro. Norris et al. devise a method to control protein complex assembly in cells and use this approach to investigate how ...
openaire +1 more source
Development of a Low-Depth Modular GHX through a Real-Scale Experiment
Energies, 2022 The global energy sector is aiming to rapidly transform energy systems into those less dependent on fossil fuels to reduce their harmful effects on the climate.
Kwonye Kim +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analysis of Seismic Performance and Applicable Height of a Cooperative Modular Steel Building
BuildingsAs an innovative building system, the modular steel structure demonstrates a high degree of industrialization and assembly efficiency. However, no linkage exists between the components of modular units, leading to issues such as diminished load capacity ...
Yan Wang, Zhuyu Huang, Qi An
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Development of Modular Building in China
DEStech Transactions on Engineering and Technology Research, 2017 Modular building is a new-type building structure, which has obvious benefits such as energy-saving, rapid construction, efficient manufacturing, and good quality, comparing with the traditional building. The technique can save Chinese construction industry from the dilemma of high pollution, high energy consumption and poor efficiency, and be of great
Yan-juan HAN, Wen-zheng ZHU
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source