Results 71 to 80 of about 3,042,953 (324)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Upper Sioux Indian Community Trip Report: Assessment of Mold and Moisture Conditions [PDF]

open access: yes, 2004
Paul Francisco from the Building Research Council (BRC) at the University of Illinois Urbana-Champaign and Robert Nemeth from Magna Systems, Inc. conducted a site visit at the Upper Sioux Indian Community Housing Department (USICHD) on April21-23, 2004 ...
Francisco, Paul, Nemeth, Robert
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Coupling problem in thermal systems simulations [PDF]

open access: yes, 2017
Building energy simulation is playing a key role in building design in order to reduce the energy consumption and, consequently, the CO2 emissions. An object-oriented tool called NEST is used to simulate all the phenomena that appear in a building.
González Esteve, Adrià
core   +1 more source

Modular residential buildings as engineering hybrids

open access: yesCurrent problems of architecture and urban planning, 2023
The article discusses the varieties of engineering hybrids - modular residential buildings. The genesis and history of modular housing construction are traced. The advantages and problems of modular housing construction are determined. The study identified modern trends in modular construction: 1) the desire for maximum consolidation of construction ...
Halyna Osychenko   +2 more
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Downtown Providence Farmers Market Design [PDF]

open access: yes, 2014
This market essentially combines a marketplace with an existing or new industrial building. The hybrid created results in space that has daily retail sales and hours, as well as other goods available at other times.
Dansereau, Lindsay   +13 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Towards an Effective Architectural Form: The Composition of Squareness and Roundness Based on Scale Proportion—Evidence from the Yingxian Wooden Pagoda

open access: yesBuildings
Investigating the mathematical and geometric principles embedded in ancient classic architecture is a significant tradition in the history of architectural development.
Lu Shi   +5 more
doaj   +1 more source

Kac-Moody Groups and Cosheaves on Davis Building [PDF]

open access: yes, 2018
We investigate smooth representations of complete Kac-Moody groups. We approach representation theory via geometry, in particular, the group action on the Davis realisation of its Bruhat-Tits building.
Hristova, Katerina, Rumynin, Dmitriy
core   +2 more sources

Home - About - Disclaimer - Privacy