Results 91 to 100 of about 3,315,782 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Modular brain construction [PDF]

Science, 2016
Neurodevelopment The mammalian cerebellum looks complex on the surface, with a stereotypical pattern of lobules and fissures. Although its subregions all seem to use similar types of cells, tracts coming from elsewhere in the brain target distinct portions of the cerebellum, suggesting that surface formations reflect functional zones.
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Use of BIM with Modular Construction in Future Construction Techniques

MANAS: Journal of Engineering
Modular construction technology and applications are rapidly evolving. Modular construction is a process in which entire rooms or sections of rooms are built in a factory setting along with electrical, mechanical, and plumbing work and then transported ...
Ali Ünay, Asena Soyluk, İlayda Omurtay
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Modular concrete construction [PDF]

, 2017
Purpose This study evaluates the enablers and barriers for modular concrete construction in Lebanon. The purpose of this paper is to investigate various factors (time, cost, technical know-how, organizational, sustainability, etc.) and their influence ...
Hamzeh, Farook R., Ghani, Omar Abdul, Bacha, Mohammad Bassel Saleh, Omar Abdul Ghani, Mohammad Bassel Saleh Bacha, Farook Hamzeh, Yara Abbas, Abbas, Yara   +7 more
core   +1 more source

Evaluating Modular House Construction Projects: A Delphi Method Enhanced by Conversational AI

Buildings
This study focuses on evaluating modular house construction projects, which is a critical segment within sustainable building practices. Despite the significant advantages of modular construction, such as enhanced resource efficiency and reduced ...
Augustinas Maceika, Andrej Bugajev, Olga R. Šostak   +2 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Adoption in the construction industry [PDF]

, 2006
This report draws together the key findings from six case studies on the subject of ebusiness\ud Adoption in Construction conducted in Australia by the University of Newcastle\ud (UON) and Royal Melbourne Institute of Technology (RMIT) from 2005 through ...

core  

CONCERT: A Modular Reconfigurable Robot for Construction

Journal of Field Robotics
ABSTRACT This paper presents CONCERT, a fully reconfigurable modular collaborative robot (cobot) for multiple on‐site operations in a construction site. CONCERT has been designed to support human activities in construction sites by leveraging two main characteristics: high‐power density motors and modularity. In this way, the robot is
Luca Rossini, Edoardo Romiti, Arturo Laurenzi, Francesco Ruscelli, Marco Ruzzon, Luca Covizzi, Lorenzo Baccelliere, Stefano Carrozzo, Michael Terzer, Marco Magri, Carlo Morganti, Maolin Lei, Liana Bertoni, Diego Vedelago, Corrado Burchielli, Stefano Cordasco, Luca Muratore, Andrea Giusti, Nikos Tsagarakis   +18 more
openaire   +2 more sources