Results 81 to 90 of about 61,713 (311)

Modular brain construction [PDF]

Science, 2016
Neurodevelopment The mammalian cerebellum looks complex on the surface, with a stereotypical pattern of lobules and fissures. Although its subregions all seem to use similar types of cells, tracts coming from elsewhere in the brain target distinct portions of the cerebellum, suggesting that surface formations reflect functional zones.
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modular construction as a promising alternative for the construction of affordable and quality housing [PDF]

MATEC Web of Conferences
This study seeks to explore the fundamental characteristics of modular construction, which covers the details of design and construction processes, from production through to assembly.
Antunes Duarte R.P.B., Lúcio Válter J.G., Pinho Fernando F.S.   +2 more
doaj   +1 more source

Habitação de interesse social em madeira conforme os princípios de coordenação modular e conectividade [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnologico, Programa de Pós-graduação em Engenharia Civil, Florianópolis, 2010O Brasil, atualmente, apresenta uma crescente área de florestas plantadas, que pode ser aplicada de ...
Espíndola, Luciana da Rosa
core  

Research Trends in Affordable Modular Housing [PDF]

This study explores the intersection of modular construction and affordable housing, emphasizing the gap between academic research and industry practice.
Park, JeeWoong, Moussavi, Pedram, Choi, Jin Ouk   +2 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Navigating Barriers to the Adoption and Scalability of Modular Construction in Ethiopia [PDF]

As a developing economy, there is an increasing demand for infrastructure in Ethiopia that necessitates faster and more scalable construction solutions.
Bouferguene, Ahmed, Al-Hussein, Mohamed, Zelele, Tadesse, Desbalo, Muluken   +3 more
core   +2 more sources

Financial Modeling for Modular and Offsite Construction [PDF]

, 2020
The advantages of using modular and offsite construction compared with the traditional construction methods are numerous due to its efficiency in delivering shorter schedules, lower cost, higher quality, and better safety.
Gareth Figgess, Hossam El-Sokkary, Hossam Elsokkary, Tarek Salama, Mohamed Elsharawy   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source