Results 231 to 240 of about 1,014,653 (280)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Phage Receptor-Binding Proteins for Targeted Silver Nanoparticle Delivery: Design and Evaluation. [PDF]

Viruses
He Q, Yang X, Qiu Z.
europepmc   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Nucleic acid nanotechnologies: transforming the future of precision medicine. [PDF]

Nanomedicine (Lond)
Afonin KA.
europepmc   +1 more source

Crowe severity and femoral stem geometry are associated with lower-limb alignment after total hip arthroplasty for unilateral developmental dysplasia of the hip-related secondary osteoarthritis: valgus alignment trajectories. [PDF]

Arch Orthop Trauma Surg
Afacan MY, Gurcinar MG, Davulcu CD, Unlu MC, Kaynak G.   +4 more
europepmc   +1 more source

Integrative Modular, Network-Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7. [PDF]

Microbiologyopen
Gambushe SM, Zishiri OT.
europepmc   +1 more source

Entropy-Driven Intelligent Diagnosis for SMR Loss of Coolant Accidents: A CNN-LSTM-Attention Hybrid Model for Break Size Assessment. [PDF]

Entropy (Basel)
Yang L, Lei J.
europepmc   +1 more source

Research on the Adhesive Strength of Different Bonding Structures for Modular Wind Turbine Blades. [PDF]

Materials (Basel)
Yang J, Jin A, Li J, Li F.
europepmc   +1 more source

Trophic ecology outweighed intrinsic constraints in shaping skull evolution of carnivorous Permian synapsids. [PDF]

Commun Biol
Warshaw EA, Singh SA, Benton MJ.
europepmc   +1 more source