Results 41 to 50 of about 624,167 (298)

Protocell design through modular compartmentalization [PDF]

Journal of The Royal Society Interface, 2013
De novo synthetic biological design has the potential to significantly impact upon applications such as energy generation and nanofabrication. Current designs for constructing organisms from component parts are typically limited in scope, as they utilize a cut-and-paste ideology to create simple stepwise engineered protein-signalling pathways.
Miller, David, Booth, Paula J, Seddon, John M, Templer, Richard H, Law, Robert V, Woscholski, Rudiger, Ces, Oscar, Barter, Laura M C   +7 more
openaire   +3 more sources

Modularity in support of design for re-use [PDF]

, 2001
We explore the structuring principle of modularity with the objective of analysing its current ability to meet the requirements of a 're-use' centred approach to design. We aim to highlight the correlation's between modular design and 're-use', and argue
Duffy, Alex H. B., Smith, Joanne S.
core  

Hierarchical modularity in human brain functional networks [PDF]

, 2009
The idea that complex systems have a hierarchical modular organization originates in the early 1960s and has recently attracted fresh support from quantitative studies of large scale, real-life networks.
Alex Fornito, Alex Fornito, Alex Fornito, David Meunier, David Meunier, Edward T Bullmore, Edward T Bullmore, Edward T Bullmore, Karen Ersche, Karen Ersche, Renaud Lambiotte   +10 more
core   +4 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Design and Climate-Responsiveness Performance Evaluation of an Integrated Envelope for Modular Prefabricated Buildings

Advances in Materials Science and Engineering, 2018
Modular prefabricated buildings effectively improve the efficiency and quality of building design and construction and represent an important trend in the development of building industrialization. However, there are still many deficiencies in the design
Junjie Li, Shuai Lu, Wanlin Wang, Jie Huang, Xinxing Chen, Jiayi Wang   +5 more
doaj   +1 more source

Techniques for improving reliability of computers [PDF]

, 1972
Modular design techniques improve methods of error detection, diagnosis, and recovery. Theoretical computer (MARCS (Modular Architecture for Reliable Computer Systems)) study deals with postulated and modeled technology indigenous to 1975-1980.
Bouricius, W. G., Cater, W. C., Jessep, D. C., Mccarthy, C. E., Milligan, F. G., Wadia, A. B.   +5 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Structuralization of customer requirements by association rule mining and design structure matrix for configure-to-order products

Nihon Kikai Gakkai ronbunshu, 2021
Structural analysis of customer data such as purchase history and customer attributes is expected to be effective for designing the products that are appropriately adapted to requirements of individual customers.
Kana SAWAI, Yutaka NOMAGUCHI, Kikuo FUJITA   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source