Results 41 to 50 of about 12,232,847 (349)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Long-Term Thermal Stability of Aerogel and Basalt Fiber Pipeline Insulation Under Simulated Atmospheric Aging

Energies
Thermal insulation materials used in power and industrial systems must maintain high performance under extreme environmental conditions. Among such materials, aerogel and basalt fiber are widely applied due to their low thermal conductivity and ease of ...
Irina Akhmetova, Alexander Fedyukhin, Anna Dontsova, Umberto Berardi, Olga Afanaseva, Kamilya Gafiatullina, Maksim Kraikov, Darya Nemova, Valeria Selicati, Roberto Stasi   +9 more
doaj   +1 more source

Structuralization of customer requirements by association rule mining and design structure matrix for configure-to-order products

Nihon Kikai Gakkai ronbunshu, 2021
Structural analysis of customer data such as purchase history and customer attributes is expected to be effective for designing the products that are appropriately adapted to requirements of individual customers.
Kana SAWAI, Yutaka NOMAGUCHI, Kikuo FUJITA   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Modular Mobile Application Design

Code4Lib Journal, 2012
This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed.
Jim Hahn, Nathaniel Ryckman
doaj  

Modular design towards the circular economy – From ‘making to unmake’ to ‘making to remake'

Agathón, 2023
Given the recent debate regarding the transition to the Circular Economy, Design for Modularity strategies play a decisive role in the process of transforming the current economic model from linear to circular.
Lucia Pietroni, Alessandro Di Stefano, Daniele Galloppo   +2 more
doaj   +1 more source

Traceability and modularity in software design [PDF]

Proceedings Ninth International Workshop on Software Specification and Design, 2002
A software design specification consists of a number of documents that describe various aspect of the design at different levels of detail, that are linked in many ways. This paper shows how different designs may use different modularization criteria, and how documents describing these designs may be linked in a coherent way, even if the designs use ...
openaire   +3 more sources

Model-based systems engineering in modular design

Design Science, 2019
Modular design allows to reduce costs based on scaling effects. However, due to strong alternating effects between the resulting modules and products, methods and tools are required that enable engineers to use specific views in which the respective ...
A. Albers, N. Bursac, Helmut Scherer, Clemens Birk, Jonas Powelske, S. Muschik   +5 more
semanticscholar   +1 more source