Results 41 to 50 of about 576,932 (353)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Learning in neuro/fuzzy analog chips [PDF]

open access: yes, 1995
This paper focus on the design of adaptive mixed-signal fuzzy chips. These chips have parallel architecture and feature electrically-controlable surface maps.
Rodríguez Vázquez, Ángel Benito   +1 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

A modular hybrid simulation framework for complex manufacturing system design [PDF]

open access: yes, 2019
For complex manufacturing systems, the current hybrid Agent-Based Modelling and Discrete Event Simulation (ABM–DES) frameworks are limited to component and system levels of representation and present a degree of static complexity to study optimal ...
Erkoyuncu, J. A.   +3 more
core   +2 more sources

Research on product innovation design of modularization based on theory of TRIZ and axiomatic design

open access: yesAdvances in Mechanical Engineering, 2018
Modular design can shorten the product development cycle and enhance the product research and development capability of enterprises. To better solve the problem of module interface coupling after module partition, the present modular product design ...
Zhong-hang Bai   +3 more
doaj   +1 more source

Modular Design of Lithium-ion Battery Packs for Cylindrical Battery Cabins of AUV

open access: yes水下无人系统学报, 2022
For autonomous undersea vehicles(AUV), the capacity and reliability of battery packs depend on their range, safety, and overall performance. According to the technical specifications of the energy system of an AUV, the 21700 lithium-ion battery was ...
De-yong SONG   +5 more
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Modularity in support of design for re-use [PDF]

open access: yes, 2001
We explore the structuring principle of modularity with the objective of analysing its current ability to meet the requirements of a 're-use' centred approach to design. We aim to highlight the correlation's between modular design and 're-use', and argue
Duffy, Alex H. B., Smith, Joanne S.
core  

Design and Climate-Responsiveness Performance Evaluation of an Integrated Envelope for Modular Prefabricated Buildings

open access: yesAdvances in Materials Science and Engineering, 2018
Modular prefabricated buildings effectively improve the efficiency and quality of building design and construction and represent an important trend in the development of building industrialization. However, there are still many deficiencies in the design
Junjie Li   +5 more
doaj   +1 more source

Developing a Modular Unmanned Aerial Vehicle (UAV) Platform for Air Pollution Profiling

open access: yesSensors, 2018
The unmanned aerial vehicle (UAV) offers great potential for collecting air quality data with high spatial and temporal resolutions. The objective of this study is to design and develop a modular UAV-based platform capable of real-time monitoring of ...
Qijun Gu   +2 more
doaj   +1 more source

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