Results 61 to 70 of about 611,376 (281)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Two approaches to the holomorphic modular bootstrap

Journal of High Energy Physics
The holomorphic bootstrap attempts to classify rational conformal field theories. The straight ahead approach is hard to implement when the number of characters become large.
Suresh Govindarajan, Jagannath Santara
doaj   +1 more source

Variation of Iwasawa invariants in Hida families

, 2004
Let r : G_Q -> GL_2(Fpbar) be a p-ordinary and p-distinguished irreducible residual modular Galois representation. We show that the vanishing of the algebraic or analytic Iwasawa mu-invariant of a single modular form lifting r implies the vanishing of ...
Emerton, Matthew, Pollack, Robert, Weston, Tom   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Quasi–eclectic modular flavor symmetries

Physics Letters B, 2022
Modular flavor symmetries provide us with a new, promising approach to the flavor problem. However, in their original formulation the kinetic terms of the standard model fields do not have a preferred form, thus introducing additional parameters, which ...
Mu–Chun Chen, Víctor Knapp–Pérez, Mario Ramos–Hamud, Saúl Ramos–Sánchez, Michael Ratz, Shreya Shukla   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Generalized Eta Transformation Formulas as the Hecke Modular Relation

Axioms
The transformation formula under the action of a general linear fractional transformation for a generalized Dedekind eta function has been the subject of intensive study since the works of Rademacher, Dieter, Meyer, and Schoenberg et al.
Nianliang Wang, Takako Kuzumaki, Shigeru Kanemitsu   +2 more
doaj   +1 more source

On three theorems of Folsom, Ono and Rhoades

, 2013
In his deathbed letter to Hardy, Ramanujan gave a vague definition of a mock modular function: at each root of unity its asymptotics matches the one of a modular form, though a choice of the modular function depends on the root of unity. Recently Folsom,
Zudilin, Wadim
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Some Fixed Point Results for Sehgal-Proinov Type Contractions in Modular b−Metric Spaces

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2023
In this paper, inspired by Proinov type contractions, we intend to acquire novel definitions and results that expand Sehgals [3] metric fixed point theory in the sense of modular b−metric space. To demonstrate the theorems, we employ a general form of (α,
Büyükkaya Abdurrahman, Öztürk Mahpeyker   +1 more
doaj   +1 more source