Results 91 to 100 of about 10,606 (255)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Hermitian modular forms and algebraic modular forms on SO(6)

Journal of Number Theory
41 ...
Tomoyoshi Ibukiyama, Brandon Williams
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Modular curves, modular forms, lattices, Galois representations

, 2011
This chapter provides the necessary background concerning modular curves and modular forms. It covers modular curves, modular forms, lattices and modular forms, Galois representations attached to eigenforms, and Galois representations over finite fields ...
Bas Edixhoven
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

MOCK THETA FUNCTIONS AND QUANTUM MODULAR FORMS

Forum of Mathematics, Pi, 2013
Ramanujan’s last letter to Hardy concerns the asymptotic properties of modular forms and his ‘mock theta functions’. For the mock theta function $f(q)$, Ramanujan claims that as $q$ approaches an even-order $2k$ root of unity, we have $$\begin{eqnarray ...
AMANDA FOLSOM, KEN ONO, ROBERT C. RHOADES   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

On some automorphic properties of Galois traces of class invariants from generalized Weber functions of level 5

Open Mathematics, 2019
After the significant work of Zagier on the traces of singular moduli, Jeon, Kang and Kim showed that the Galois traces of real-valued class invariants given in terms of the singular values of the classical Weber functions can be identified with the ...
Eum Ick Sun, Jung Ho Yun
doaj   +1 more source

All-order differential equations for one-loop closed-string integrals and modular graph forms

Journal of High Energy Physics, 2020
We investigate generating functions for the integrals over world-sheet tori appearing in closed-string one-loop amplitudes of bosonic, heterotic and type-II theories.
Jan E. Gerken, Axel Kleinschmidt, Oliver Schlotterer   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source