Results 271 to 280 of about 178,806 (344)

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Design of Cascaded Modular Multilevel Converter for Grid Connected PV System

, 2019
Tetali Swathi, Narasimha Raju V S N, Sainadh Singh K, Srinivas Reddy G   +3 more
openalex   +1 more source

Epistemic limits of local interpretability in self-modulating cognitive architectures. [PDF]

Front Artif Intell
Mahrouk A.
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Clinical efficacy of personalized 3D-printed modular navigation templates in assisting Femoral Neck System implantation for femoral neck fractures in young and middle-aged adults. [PDF]

BMC Musculoskelet Disord
Sheng X, Qian J, Zhu Y, Sha W, Tian S, Huang Y, Ge J.   +6 more
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

An end-to-end deep learning pipeline for hematoma expansion prediction in spontaneous intracerebral hemorrhage based on non-contrast computed tomography. [PDF]

NPJ Digit Med
Yu Q, Fan X, Li J, Hao Q, Ning Y, Long S, Jiang W, Lv F, Yan X, Liu Q, Xu X, Wu Z, Peng J, Wu M.   +13 more
europepmc   +1 more source

Integration of modular multilevel converters and soft computing for efficient grid-connected PV systems

P Manimala, Sujatha Balaraman, C. John De Britto, M. Hariprabhu   +3 more
openalex   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Disrupted modular and hub topology in right temporal lobe epilepsy: a multimodal MRI network analysis. [PDF]

Front Neurol
Qu C, Zheng J, Chen Z, Luo C, Huang D, Fan L.   +5 more
europepmc   +1 more source