Results 31 to 40 of about 58,936 (221)

Some Fixed Point Theorems on Compact Modular Metric Spaces

Proceedings of the Institute of Mathematics and Mechanics,National Academy of Sciences of Azerbaijan, 2020
Summary: In this article, we prove some fixed point theorems for contractive mappings in compact modular metric spaces. Then we illustrate our main theorem with an example. The application of the obtained result is also discussed.
Ozkan, Kubra, Gurdal, Utku, Mutlu, Ali
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

From fuzzy metric spaces to modular metric spaces: a fixed point approach

The Journal of Nonlinear Sciences and Applications, 2017
Summary: We propose an intuitive theorem which uses some concepts of auxiliary functions for establishing existence and uniqueness of the fixed point of a self-mapping. First we work in the setting of fuzzy metric spaces in the sense of George and Veeramani, then we deduce some consequences in modular metric spaces. Finally, a sample homotopy result is
Tchier, Fairouz, Vetro, Calogero, Vetro, Francesca   +2 more
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Robert MacPherson and arithmetic groups [PDF]

, 2006
We survey contributions of Robert MacPherson to the theory of arithmetic groups. There are two main areas we discuss: (i) explicit reduction theory for Siegel modular threefolds, and (ii) constructions of compactifications of locally symmetric spaces ...
Gunnells, Paul E.
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Cop and robber game and hyperbolicity

, 2014
In this note, we prove that all cop-win graphs G in the game in which the robber and the cop move at different speeds s and s' with s'0, this establishes a new - game-theoretical - characterization of Gromov hyperbolicity.
Chalopin, Jérémie, Chepoi, Victor, Papasoglu, Panos, Pecatte, Timothée   +3 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

FIXED POINT OF MULTIVALUED CONTRACTIONS IN ORTHOGONAL MODULAR METRIC SPACES [PDF]

Facta Universitatis, Series: Mathematics and Informatics, 2019
In this paper we generalize the notion of O−set and establish some fixedpoint theorems for ⊥ − α − ψ−contraction multifunction in the setting of orthogonalmodular metric spaces. As consequences of these results we deduce some theorems inorthogonal modular metric spaces endowed with a graph and partial order.
Hosseini, Hoda, Gordji, Majid Eshaghi
openaire   +2 more sources