Results 51 to 60 of about 3,458 (239)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The Meir-Keeler type contractions in extended modular b-metric spaces with an application

, 2021
In this paper, we introduce the notion of a modular p-metric space (an extended modular b-metric space) and establish some fixed point results for alpha-nu-Meir-Keeler contractions in this new space.
Gholidahneh, Abdolsattar, Sedghi, Shaban, de la Sen, Manuel, Ege, Ozgur, Mitrovic, Zoran D.   +4 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Modular spaces and topologies on modular spaces

, 2023
Yüksek Lisans TeziTezimiz dört bölümden oluşmaktadır. Birinci bölümde metrik uzaylar ve modüler metrik ile ilgili genel bilgi verilerek matematikteki tarihsel gelişimi verilmiştir.
Haşimoğlu, Firdevs
core  

On Asymptotic Pointwise Contractions in Modular Metric Spaces [PDF]

, 2020
In this paper we study and prove some new fixed points theorems for pointwise and asymptotic pointwise contraction mappings in modular metric ...
Afrah A N Abdou
core  

On one-local retract in modular metrics [PDF]

Categories and General Algebraic Structures with Applications
We continue the study of the concept of one local retract in the settings of modular metrics. This concept has been studied in metric spaces and quasi-metric spaces by different authors with different motivations.
Oliver Olela Otafudu, Tlotlo Odacious Phawe   +1 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

From fuzzy metric spaces to modular metric spaces: a fixed point approach

, 2017
We propose an intuitive theorem which uses some concepts of auxiliary functions for establishing existence and uniqueness of the fixed point of a self-mapping. First we work in the setting of fuzzy metric spaces in the sense of George and Veeramani, then
Fairouz Tchier, Francesca Vetro, Calogero Vetro, C. Vetro, F. Tchier, F. Vetro   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Generalized modular fractal spaces and fixed point theorems

Advances in Difference Equations, 2021
In this article, we introduce a new concept of Hausdorff distance through generalized modular metric on nonempty compact subsets and study some topological properties of it.
Alireza Alihajimohammad, Reza Saadati
doaj   +1 more source