Results 51 to 60 of about 1,769,204 (265)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Fixed point results for generalized F-contractions in modular metric and fuzzy metric spaces [PDF]

Fixed Point Theory and Applications, 2015
AbstractThe notion of modular metric space, being a natural generalization of classical modulars over linear spaces, was recently introduced. In this paper, we introduce a generalized F-contraction in modular metric space and investigate the existence of fixed points for such contractions.
Nawab Hussain, Abdul Latif, Iram Iqbal
openaire   +2 more sources

On one-local retract in modular metrics [PDF]

Categories and General Algebraic Structures with Applications
We continue the study of the concept of one local retract in the settings of modular metrics. This concept has been studied in metric spaces and quasi-metric spaces by different authors with different motivations.
Oliver Olela Otafudu, Tlotlo Odacious Phawe   +1 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Some fixed point theorems on complex valued modular metric spaces with an application

, 2021
In this article, we introduce the notion of complex valued modular metric spaces. We also a prove generalization of Banach Fixed Point Theorem, which is one of the most simple and significant tests for existence and uniqueness of solution of problems ...
Özkan, Kübra
core   +2 more sources

Some Fixed Point Theorems on Compact Modular Metric Spaces

Proceedings of the Institute of Mathematics and Mechanics,National Academy of Sciences of Azerbaijan, 2020
Summary: In this article, we prove some fixed point theorems for contractive mappings in compact modular metric spaces. Then we illustrate our main theorem with an example. The application of the obtained result is also discussed.
Ozkan, Kubra, Gurdal, Utku, Mutlu, Ali
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Generalized modular fractal spaces and fixed point theorems

Advances in Difference Equations, 2021
In this article, we introduce a new concept of Hausdorff distance through generalized modular metric on nonempty compact subsets and study some topological properties of it.
Alireza Alihajimohammad, Reza Saadati
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source