Results 31 to 40 of about 12,509 (219)
Frontiers in Neurorobotics, 2013 Curiosity Driven Modular Incremental Slow Feature Analysis (CD-MISFA;~cite{cdmisfa}) is a recently introduced model of intrinsically-motivated invariance learning, which shows how curiosity enables the orderly formation of multiple stable sensory ...
Matthew David Luciw +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Rescorla-Wagner drift-diffusion model of conditioning and timing. [PDF]
PLoS Computational Biology, 2017 Computational models of classical conditioning have made significant contributions to the theoretic understanding of associative learning, yet they still struggle when the temporal aspects of conditioning are taken into account.
André Luzardo +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
On the Virasoro crossing kernels at rational central charge
SciPost PhysicsWe report novel analytic results for the Virasoro modular and fusion kernels relevant to 2d conformal field theories (CFTs), 3d topological field theories (TQFTs), and the representation theory of certain quantum groups.
Julien Roussillon, Ioannis Tsiares
doaj +1 more source
BRAPH: A graph theory software for the analysis of brain connectivity. [PDF]
PLoS ONE, 2017 The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the ...
Mite Mijalkov +5 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Frontiers in Energy Research, 2021 AC/DC hybrid distribution network can realize the high penetration utilization of renewable energy and modular multilevel converter (MMC) is the key equipment to connect AC grid and DC grid.
Zhang Xianyong +7 more
doaj +1 more source