Results 71 to 80 of about 15,050 (265)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On the Virasoro fusion kernel at $c=25$
SciPost PhysicsWe find a formula for the Virasoro fusion kernel at $c=25$, in terms of the connection coefficients of the Painlevé VI differential equation. Our formula agrees numerically with previously known integral representations of the kernel.
Sylvain Ribault, Ioannis Tsiares
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A radiative neutrino mass model with leptoquarks under non-holomorphic modular A 4 symmetry
Journal of High Energy PhysicsWe investigate a radiative seesaw model with two leptoquarks under non-holomorphic modular A 4 symmetry. The leptons and quarks belong to non-trivial representations of the modular A 4 and the structures of their mass matrices are restricted.
Takaaki Nomura +2 more
doaj +1 more source
The Ramanujan and Sato–Tate Conjectures for Bianchi modular forms
Forum of Mathematics, PiWe prove the Ramanujan and Sato–Tate conjectures for Bianchi modular forms of weight at least $2$ . More generally, we prove these conjectures for all regular algebraic cuspidal automorphic representations of $\operatorname {\mathrm {GL}}_2 ...
George Boxer +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Computing modular Galois representations [PDF]
Rendiconti del Circolo Matematico di Palermo, 2013 Fifth version changes : Rewritten the technical part of the introduction, and corrected a few ...
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The eclectic flavor symmetries of T 2 / ℤ K $$ {\mathbbm{T}}^2/{\mathbb{Z}}_K $$ orbifolds
Journal of High Energy PhysicsOnly four T 2 / ℤ K $$ {\mathbbm{T}}^2/{\mathbb{Z}}_K $$ orbifold building blocks are admissible in heterotic string compactifications. We investigate the flavor properties of all of these building blocks.
Alexander Baur +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source