Results 81 to 90 of about 80,665 (262)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Modular Design of Interfaces in Nanostructures from Quasicrystalline Blocks

Известия высших учебных заведений России: Радиоэлектроника
Introduction. Aperiodic order offers the possibility of creating new materials and structures with nonstandard properties. Active research is currently underway to obtain materials from non-atom building blocks, materials and elements based on aperiodic ...
A. E. Madison, P. A. Madison, V. A. Moshnikov, A. V. Solomonov   +3 more
doaj   +1 more source

The Hierarchical Modular Structure of HER2+ Breast Cancer Network

Frontiers in Physiology, 2018
HER2-enriched breast cancer is a complex disease characterized by the overexpression of the ERBB2 amplicon. While the effects of this genomic aberration on the pathology have been studied, genome-wide deregulation patterns in this subtype of cancer are ...
Sergio Antonio Alcalá-Corona, Sergio Antonio Alcalá-Corona, Jesús Espinal-Enríquez, Jesús Espinal-Enríquez, Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +6 more
doaj   +1 more source

Cryo-EM tomography and automatic segmentation delineate modular structures in the postsynaptic density. [PDF]

Front Synaptic Neurosci, 2023
Jung JH, Chen X, Reese TS.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Modular shape-changing tensegrity-blocks enable self-assembling robotic structures

Nature Communications
Modular robots are currently designed to perform a variety of tasks, primarily focusing on locomotion or manipulation through the reconfiguration of rigid modules.
Luyang Zhao, Yitao Jiang, Muhao Chen, Kostas Bekris, Devin Balkcom   +4 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Characterizing multiscale modular structures in medication-free obsessive-compulsive disorder patients with no comorbidity. [PDF]

Hum Brain Mapp, 2022
Li X, Li H, Jiang X, Li J, Cao L, Liu J, Xing H, Huang X, Gong Q.   +8 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source