Results 61 to 70 of about 80,665 (262)

Network Modularity in Breast Cancer Molecular Subtypes

Frontiers in Physiology, 2017
Breast cancer is a heterogeneous and complex disease, a clear manifestation of this is its classification into different molecular subtypes. On the other hand, gene transcriptional networks may exhibit different modular structures that can be related to ...
Sergio Antonio Alcalá-Corona, Sergio Antonio Alcalá-Corona, Guillermo de Anda-Jáuregui, Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Jesús Espinal-Enríquez, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Long-Term Thermal Stability of Aerogel and Basalt Fiber Pipeline Insulation Under Simulated Atmospheric Aging

Energies
Thermal insulation materials used in power and industrial systems must maintain high performance under extreme environmental conditions. Among such materials, aerogel and basalt fiber are widely applied due to their low thermal conductivity and ease of ...
Irina Akhmetova, Alexander Fedyukhin, Anna Dontsova, Umberto Berardi, Olga Afanaseva, Kamilya Gafiatullina, Maksim Kraikov, Darya Nemova, Valeria Selicati, Roberto Stasi   +9 more
doaj   +1 more source

The Influence of Inter-Connections Characteristics on the Lateral Performance of Braced-Frame Modular Steel Buildings [PDF]

Journal of Rehabilitation in Civil Engineering
The use of pre-fabricated modular units for the construction of mid to high-rise buildings has been promoted recently. The modular units are fabricated in a factory and then transported to the construction site to form a structure using inter-connections.
Mostafa Farajian, Mohammad Iman Khodakarami   +1 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

3D printed modular Bouligand dissipative structures with adjustable mechanical properties for gradient energy absorbing

Materials Futures
Three-dimensional (3D) printing allows for the creation of complex, layered structures with precise micro and macro architectures that are not achievable through traditional methods.
Junfeng Xiao, Mengxing Zhang, Fei Zhai, Hongrui Wei, Sen Liu, Peng Wang, Zhiyang Liu, Zhongying Ji, Xiaolong Wang   +8 more
doaj   +1 more source

Flavor structures of quarks and leptons from flipped SU(5) GUT with A 4 modular flavor symmetry

Journal of High Energy Physics, 2023
We propose to generate the flavor structures of the Standard Model plus neutrinos from flipped SU(5) GUT with A 4 modular flavor symmetry. Possible way to assign different moduli values for quarks and leptons in modular GUT scheme is discussed.
Xiao Kang Du, Fei Wang
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Anti-modularization for both high robustness and efficiency including the optimal case.

PLoS ONE
Although robustness of connectivity and modular structures in networks have been attracted much attentions in complex networks, most researches have focused on those two features in Erdos-Renyi random graphs and Scale-Free networks whose degree ...
Jaeho Kim, Yukio Hayashi
doaj   +1 more source

Topological interlocking as a principle of engineering design in consruction of marine and coastal structures

Записки Горного института, 2017
As a discussion contribution, a new concept for solving problems of bank protection structures based on topological interlocking is presented, which opens up a way to obtaining new segmented or modular designs of building elements and structures.
V. Yu. Piirainen, Yu. Z. Estrin
doaj   +1 more source