Results 141 to 150 of about 191,998 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Turbo Detection of Channel-Coded Space-Time Signals Using Sphere Packing Modulation [PDF]

, 2004
A recently proposed space-time signal construction method that combines orthogonal design with sphere packing, referred to here as (STBC-SP), has shown useful performance improvements over Alamouti’s conventional orthogonal design.
Alamri, O., B. L. Yeap, Yeap, B.L., O. Alamri, L. Hanzo, Hanzo, L.   +5 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Equalization and Coding Techniques for Edge Modulation Signaling

IEEE Open Journal of Circuits and Systems
This paper describes equalization, coding, and crosstalk reduction techniques for edge modulation signaling. We analyze the inter-symbol interference of edge modulation using enumeration method and present expressions for the error rate from inter-edge ...
Richelle L. Smith, Shakib Mahmood, Carl W. Werner, Thomas H. Lee, Masum Hossain   +4 more
doaj   +1 more source

Coded Modulation Assisted Genetic Algorithm Based Multiuser Detection for CDMA Systems [PDF]

, 2002
In this contribution we propose a novel Coded Modulation assisted Genetic Algorithm based Multiuser Detection (CM-GA-MUD) scheme for synchronous CDMA systems.
Ng, S.X., Ng, S. X., Hanzo, L., Yen, K.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Space-Time Spreading Assisted Multicarrier DS-CDMA System using OVSF Codes Employing Adaptive Mode Switching Thresholds and Adaptive Modulation [PDF]

, 2005
The Concept of Space-Time Spreading (STS) assisted, Adaptive Quadrature Amplitude Modulation (AQAM) aidedMC DS-CDMAis introduced. The AQAMmode-switching thresholds are determined using an on-line real-time Bit-Error-Ratio (BER) based learning procedure ...
Wei, H, Yang, L-L., Hanzo, L.
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Differential Turbo Detection Aided Sphere Packing Modulated Space-Time Coding Scheme [PDF]

, 2006
A signal construction method that combines orthogonal design with sphere packing has recently shown useful performance improvements over the conventional orthogonal design.
Alamri, O., Wu, N., Hanzo, L.
core