Results 111 to 120 of about 517,162 (287)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Efficient Hardware Design of DNN for RF Signal Modulation Recognition Employing Ternary Weights

IEEE Access
This paper presents an efficient deep neural network (DNN) accelerator designed for radio frequency (RF) signal modulation recognition. A novel DNN design optimized for mobile applications is demonstrated by combining MobileNetV3-based DNN with a ternary
Jongseok Woo, Kuchul Jung, Saibal Mukhopadhyay   +2 more
doaj   +1 more source

Modulation recognition method of mixed signals based on cyclic spectrum projection. [PDF]

Sci Rep, 2023
Yang W, Ren K, Du Y, Zheng J, Ping Y, Wang S, Yang X, Li L.   +7 more
europepmc   +1 more source

Digital modulation recognition

, 2020
In this thesis work, automatic recognition algorithms for digital modulated signals are surveyed.Feature extraction and classification algorithm stages are the main parts of a modulation recognition system. Performance of the modulation recognition system mainly depends on the prior knowledge of some of the signal parameters, selection of the key ...
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modulation recognition driven by signal enhancement

Dianxin kexue
The existing modulation recognition algorithms based on deep learning theory require a large number of IQ signal samples during the training phase. It is difficult to obtain a large number of samples in complex electromagnetic environments, resulting in ...
CHENG Fengyun, ZHOU Jin
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Direction of Arrival Joint Prediction of Underwater Acoustic Communication Signals Using Faster R-CNN and Frequency–Azimuth Spectrum

Remote Sensing
Utilizing hydrophone arrays for detecting underwater acoustic communication (UWAC) signals leverages spatial information to enhance detection efficiency and expand the perceptual range.
Le Cheng, Yue Liu, Bingbing Zhang, Zhengliang Hu, Hongna Zhu, Bin Luo   +5 more
doaj   +1 more source

Deep Learning-Aided Modulation Recognition for Non-Orthogonal Signals. [PDF]

Sensors (Basel), 2023
Fan J, Wu L, Zhang J, Dong J, Wen Z, Zhang Z.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source